Two New Oleanane-type Triterpenoids from Methanolyzed Saponins of Momordica cochinchinensis

被引：0

作者：

Fan, Rong ^{[1
,2
]}

Cheng, Rong-Rong ^{[1
]}

Zhu, Hong-Tao ^{[1
]}

Wang, Dong ^{[1
]}

Yang, Chong-Ren ^{[1
]}

Xu, Min ^{[1
]}

Zhang, Ying-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[2] Yunnan Univ Tradit Chinese Med, Kunming 650500, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 06期

基金：

中国科学院西部之光基金;

关键词：

Momordica cochinchinensis; Oleanane-type triterpenoid saponins; Cytotoxic activity; Glucose uptake activity; CONSTITUENTS; INSULIN; SPRENG; ACID;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new oleanane-type triterpenoid saponins (1 and 2) were isolated from the methanolyzed total saponins of the seeds of Momordica cochinchinensis (Lour.) Spreng, together with 16 known compounds (3-18). Their structures were elucidated on the basis of detailed spectroscopic, including 1D and 2D NMR, mass spectrometric, methanolysis and LC-MS analysis. All the isolates were tested for their cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, PANC-1, A-549, and SW-480) and the glucose uptake activity. The known compound 6 exhibited toxic effects against HL-60 with an IC50 value of 18.1 mu M, while 10 showed cytotoxicity against SMMC-7721 and A-549 cell lines, with IC50 values of 34.4 and 32.8 mu M, respectively. In addition, the new compound 2 showed glucose uptake activity with a glucose consumption value of 0.29 mu M at 10 mu M concentration.

引用

页码：725 / 728

页数：4

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