Fluoroform-Derived CuCF3 for Trifluoromethylation of Terminal and TMS-Protected Alkynes

被引：56

作者：

He, Lisi ^{[1
]}

Tsui, Gavin Chit ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 12期

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; NUCLEOPHILIC TRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; DIRECT CUPRATION; MEDIATED TRIFLUOROMETHYLATION; EFFICIENT PRECURSOR; CARBONYL-COMPOUNDS; FLUORINE; DIFLUOROMETHYLATION;

D O I：

10.1021/acs.orglett.6b00999

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient trifluoromethylation reaction of alkynes using a fluoroform-derived CuCF3 reagent is described. The CF3 source is the inexpensive industrial waste fluoroform (CF3H). The air-stable CuCF3 reagent can be prepared in large quantities and is convenient to use. Synthetically useful trifluoromethylated alkynes containing a wide range of functional groups were successfully synthesized under mild conditions. Both terminal and TMS-protected alkynes gave the products in one step. The beneficial effect of a diamine ligand tetramethylethylenediamine (TMEDA) with the fluoroform-derived CuCF3 reagent was also demonstrated.

引用

页码：2800 / 2803

页数：4

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