Prevalence of Anti-tissue Transglutaminase Antibodies and Celiac Disease in Children With Inflammatory Bowel Disease

被引：12

作者：

Alper, Arik ^{[1
]}

Rojas-Velasquez, Danilo ^{[1
]}

Pashankar, Dinesh S. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Div Pediat Gastroenterol, New Haven, CT 06520 USA

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2018年 / 66卷 / 06期

关键词：

celiac disease; inflammatory bowel disease; tissue transglutaminase; ULCERATIVE-COLITIS; FEATURES; IBD;

D O I：

10.1097/MPG.0000000000001877

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: Celiac disease can occur in children with inflammatory bowel disease (IBD) and poses a diagnostic challenge. We evaluated the presence of anti-tissue transglutaminase (tTG) antibodies and celiac disease among children with IBD. Methods: In a retrospective chart review, we assessed the prevalence of tTG antibodies and celiac disease and compared with a control group of children with gastrointestinal symptoms without IBD. Results: Study population included 130 children with IBD and 257 in the control group. Abnormal tTG levels were found in 6 and 20 patients, respectively (4.6% vs 7.8%, P = 0.24). One patient with IBD and 12 in the control group had celiac disease (0.8% vs 4.7%, P = 0.07). Conclusions: False-positive tTG can occur in children with IBD. The prevalence of celiac disease is not increased in children with IBD compared with non-IBD children with gastrointestinal symptoms and is similar to that in the general population.

引用

页码：934 / 936

页数：3

共 16 条

[1] Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children [J].

Alper, Arik ;

Hardee, Steven ;

Rojas-Velasquez, Danilo ;

Escalera, Sandra ;

Morotti, Raffaella A. ;

Pashankar, Dinesh S. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2016, 62 (02) :314-316

[2] IgA and IgG tissue transglutaminase antibody prevalence and clinical significance in connective tissue diseases, inflammatory bowel disease, and primary biliary cirrhosis [J].

Bizzaro, N ;

Villalta, D ;

Tonutti, E ;

Doria, A ;

Tampoia, M ;

Bassetti, D ;

Tozzoli, R .

DIGESTIVE DISEASES AND SCIENCES, 2003, 48 (12) :2360-2365

[3]

Cadahía V., 2005, Rev. esp. enferm. dig., V97, P907, DOI 10.4321/s1130-01082005001200007

[4] Prevalence of celiac disease in inflammatory bowel diseases: An IG-IBD multicentre study [J].

Casella, Giovanni ;

D'Inca, Renata ;

Oliva, Lydia ;

Daperno, Marco ;

Saladino, Valeria ;

Zoli, Giorgio ;

Annese, Vito ;

Fries, Walter ;

Cortellezzi, Claudio .

DIGESTIVE AND LIVER DISEASE, 2010, 42 (03) :175-178

[5] Celiac Disease in a Child With Ulcerative Colitis A Possible Genetic Association [J].

Cheng, Sam X. ;

Raizner, Aileen ;

Phatak, Uma P. ;

Cho, Judy H. ;

Pashankar, Dinesh S. .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2013, 47 (02) :127-129

[6] Anti-tissue transglutaminase antibodies in inflammatory bowel disease: new evidence [J].

Di Tola, M ;

Sabbatella, L ;

Anania, MC ;

Viscido, A ;

Caprilli, R ;

Pica, R ;

Paoluzi, P ;

Picarelli, A .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2004, 42 (10) :1092-1097

[7] Presence of anti-'tissue' transglutaminase antibodies in inflammatory intestinal diseases: an apoptosis-associated event? [J].

Farrace, MG ;

Picarelli, A ;

Di Tola, M ;

Sabbatella, L ;

Marchione, OP ;

Ippolito, G ;

Piacentini, M .

CELL DEATH AND DIFFERENTIATION, 2001, 8 (07) :767-770

[8] Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features [J].

Hardee, Steven ;

Alper, Arik ;

Pashankar, Dinesh S. ;

Morotti, Raffaella A. .

PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2014, 17 (06) :450-454

[9] European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease [J].

Husby, S. ;

Koletzko, S. ;

Korponay-Szabo, I. R. ;

Mearin, M. L. ;

Phillips, A. ;

Shamir, R. ;

Troncone, R. ;

Giersiepen, K. ;

Branski, D. ;

Catassi, C. ;

Lelgeman, M. ;

Maki, M. ;

Ribes-Koninckx, C. ;

Ventura, A. ;

Zimmer, K. P. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2012, 54 (01) :136-160

[10] Celiac disease, collagenous sprue and microscopic colitis in IBD. Observations from a population-based cohort of IBD (ICURE) [J].

Ronnblom, Anders ;

Holmstrom, Tommy ;

Tanghoj, Hans ;

Wanders, Alkwin ;

Sjoberg, Daniel .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2015, 50 (10) :1234-1240

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