Linezolid-resistant, vancomycin-resistant Enterococcus faecium infection in patients without prior exposure to linezolid

被引：99

作者：

Rahim, S

Pillai, SK

Gold, HS

Venkataraman, L

Inglima, K

Press, RA

机构：

[1] NYU Med Ctr, Div Infect Dis, New York, NY 10016 USA

[2] NYU Med Ctr, Dept Clin Microbiol, New York, NY 10016 USA

[3] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA

[4] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA

[5] Harvard Univ, Sch Med, Boston, MA USA

来源：

CLINICAL INFECTIOUS DISEASES | 2003年 / 36卷 / 11期

关键词：

D O I：

10.1086/374929

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe 2 patients without prior exposure to linezolid who were infected with closely related strains of linezolid- and vancomycin-resistant Enterococcus faecium (LRVREF) that may have been hospital acquired. Polymerase chain reaction amplification of the domain V region of the 23S ribosomal RNA gene demonstrated the presence of the G2576U mutation previously reported to be associated with linezolid resistance. Nosocomial transmission of LRVREF is an ominous sign and underscores the importance of meticulous infection-control measures.

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页码：E146 / E148

页数：3

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