Plasmodium falciparum glutathione metabolism and growth are independent of glutathione system of host erythrocyte

被引：41

作者：

Ayi, K

Cappadoro, M

Branca, M

Turrini, F

Arese, P

机构：

[1] Univ Turin, Dipartimento Genet Biol & Biochim, I-10126 Turin, Italy

[2] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

FEBS LETTERS | 1998年 / 424卷 / 03期

关键词：

glutathione; malaria (Plasmodium falciparum); G6PD deficiency (Mediterranean variant); anti-oxidant defense;

D O I：

10.1016/S0014-5793(98)00185-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmodium falciparum parasites grew normally in glutathione (GSH)-depleted normal and G6PD-deficient (Mediterranean variant) erythrocytes (RBC), Growth inhibition was observed only at less than approximately 6-12% residual GSH. Parasites studied separately with the Sendai virus technique synthesized GSH de novo and regenerated reduced GSH 10-20 times faster than non-parasitized RBC. Electron spin resonance measurement of Tempol reduction indicated that the ability to reduce free radicals,vas restricted to the parasite, The marked efflux of oxidized GSH was mainly derived from the parasite, In conclusion, parasites are endowed with powerful and host-independent mechanisms which de novo synthesize or regenerate GSH and allow undisturbed parasite development in GSH-depleted RBC, (C) 1998 Federation of European Biochemical Societies.

引用

页码：257 / 261

页数：5

共 31 条

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