Progress toward understanding the molecular mechanisms of neurotrophic factor signalling

被引：17
作者：
Gunn-Moore, FJ [1 ]
Tavaré, JM [1 ]
机构：
[1] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
来源：
CELLULAR SIGNALLING | 1998年 / 10卷 / 03期
基金：
英国惠康基金;
关键词：
primary neurons; neurotrophic factors; signalling; tyrosine phosphorylation; protein kinases;
D O I：
10.1016/S0898-6568(97)00114-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Understanding the mechanism of action of the neurotrophic factors is central to unravelling of the mysteries of some of the neurodegenerative disorders. In this review we will discuss recent advances in our understanding of neurotrophic factor signalling in primary cultured neurons, in particular those from the superior cervical and dorsal root ganglia, as well as cerebellar granule cells, cortical neurons and oligodendrocytes. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：151 / 157
页数：7
相关论文
共 82 条
  • [1] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
    Alessi, DR
    James, SR
    Downes, CP
    Holmes, AB
    Gaffney, PRJ
    Reese, CB
    Cohen, P
    [J]. CURRENT BIOLOGY, 1997, 7 (04) : 261 - 269
  • [2] NERVE GROWTH-FACTOR AND ITS LOW-AFFINITY RECEPTOR PROMOTE SCHWANN-CELL MIGRATION
    ANTON, ES
    WESKAMP, G
    REICHARDT, LF
    MATTHEW, WD
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (07) : 2795 - 2799
  • [3] Apoptosis - Life-death balance within the cell
    Barinaga, M
    [J]. SCIENCE, 1996, 274 (5288) : 724 - 724
  • [4] PHOSPHOTYROSINE RESIDUES IN THE NERVE-GROWTH-FACTOR RECEPTOR (TRK-A) - THEIR ROLE IN THE ACTIVATION OF INOSITOLPHOSPHOLIPID METABOLISM AND PROTEIN-KINASE CASCADES IN PHEOCHROMOCYTOMA (PC12) CELLS
    BAXTER, RM
    COHEN, P
    OBERMEIER, A
    ULLRICH, A
    DOWNES, CP
    DOZA, YN
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 234 (01): : 84 - 91
  • [5] The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase
    Beltman, J
    McCormick, F
    Cook, SJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (43) : 27018 - 27024
  • [6] INVOLVEMENT OF RAS P21 IN NEUROTROPHIN-INDUCED RESPONSE OF SENSORY, BUT NOT SYMPATHETIC NEURONS
    BORASIO, GD
    MARKUS, A
    WITTINGHOFER, A
    BARDE, YA
    HEUMANN, R
    [J]. JOURNAL OF CELL BIOLOGY, 1993, 121 (03) : 665 - 672
  • [7] DIFFERENTIAL REGULATION OF P21(RAS) ACTIVATION IN NEURONS BY NERVE GROWTH-FACTOR AND BRAIN-DERIVED NEUROTROPHIC FACTOR
    CARTER, BD
    ZIRRGIEBEL, U
    BARDE, YA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) : 21751 - 21757
  • [8] Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75
    Carter, BD
    Kaltschmidt, C
    Kaltschmidt, B
    Offenhauser, N
    BohmMatthaei, R
    Baeuerle, PA
    Barde, YA
    [J]. SCIENCE, 1996, 272 (5261) : 542 - 545
  • [9] Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75
    CasacciaBonnefil, P
    Carter, BD
    Dobrowsky, RT
    Chao, MV
    [J]. NATURE, 1996, 383 (6602) : 716 - 719
  • [10] THE P75 NEUROTROPHIN RECEPTOR
    CHAO, MV
    [J]. JOURNAL OF NEUROBIOLOGY, 1994, 25 (11): : 1373 - 1385
123456789