The Extracellular Matrix Glycoprotein Tenascin C and Adult Neurogenesis

被引：25

作者：

Tucic, Milena ^{[1
]}

Stamenkovic, Vera ^{[1
]}

Andjus, Pavle ^{[1
]}

机构：

[1] Univ Belgrade, Fac Biol, Ctr Laser Microscopy, Inst Physiol & Biochem Jean Giaja, Belgrade, Serbia

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

tenascin C; adult neurogenesis; subgranular zone; subventricular zone; astrocyte; microglia; stem cell migration; NEURAL PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; OLFACTORY-BULB; ENRICHED ENVIRONMENT; STEM-CELLS; SYNAPTIC PLASTICITY; SUBVENTRICULAR ZONE; GENE-REGULATION; VASCULAR NICHE; NEURONS;

D O I：

10.3389/fcell.2021.674199

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tenascin C (TnC) is a glycoprotein highly expressed in the extracellular matrix (ECM) during development and in the adult central nervous system (CNS) in regions of active neurogenesis, where neuron development is a tightly regulated process orchestrated by extracellular matrix components. In addition, newborn cells also communicate with glial cells, astrocytes and microglia, indicating the importance of signal integration in adult neurogenesis. Although TnC has been recognized as an important molecule in the regulation of cell proliferation and migration, complete regulatory pathways still need to be elucidated. In this review we discuss the formation of new neurons in the adult hippocampus and the olfactory system with specific reference to TnC and its regulating functions in this process. Better understanding of the ECM signaling in the niche of the CNS will have significant implications for regenerative therapies.

引用

页数：12

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