The Extracellular Matrix Glycoprotein Tenascin C and Adult Neurogenesis

被引：32
作者：
Tucic, Milena [1 ]
Stamenkovic, Vera [1 ]
Andjus, Pavle [1 ]
机构：
[1] Univ Belgrade, Fac Biol, Ctr Laser Microscopy, Inst Physiol & Biochem Jean Giaja, Belgrade, Serbia
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
关键词：
tenascin C; adult neurogenesis; subgranular zone; subventricular zone; astrocyte; microglia; stem cell migration; NEURAL PROGENITOR CELLS; HIPPOCAMPAL NEUROGENESIS; OLFACTORY-BULB; ENRICHED ENVIRONMENT; STEM-CELLS; SYNAPTIC PLASTICITY; SUBVENTRICULAR ZONE; GENE-REGULATION; VASCULAR NICHE; NEURONS;
D O I：
10.3389/fcell.2021.674199
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tenascin C (TnC) is a glycoprotein highly expressed in the extracellular matrix (ECM) during development and in the adult central nervous system (CNS) in regions of active neurogenesis, where neuron development is a tightly regulated process orchestrated by extracellular matrix components. In addition, newborn cells also communicate with glial cells, astrocytes and microglia, indicating the importance of signal integration in adult neurogenesis. Although TnC has been recognized as an important molecule in the regulation of cell proliferation and migration, complete regulatory pathways still need to be elucidated. In this review we discuss the formation of new neurons in the adult hippocampus and the olfactory system with specific reference to TnC and its regulating functions in this process. Better understanding of the ECM signaling in the niche of the CNS will have significant implications for regenerative therapies.
引用
收藏
页数：12
相关论文
共 50 条
[11]   Fluoxetine-Induced Cortical Adult Neurogenesis [J].
Ohira, Koji ;
Takeuchi, Rika ;
Shoji, Hirotaka ;
Miyakawa, Tsuyoshi .
NEUROPSYCHOPHARMACOLOGY, 2013, 38 (06) :909-920
[12]   The role of adult neurogenesis in psychiatric and cognitive disorders [J].
Apple, Deana M. ;
Fonseca, Rene Solano ;
Kokovay, Erzsebet .
BRAIN RESEARCH, 2017, 1655 :270-276
[13]   Factors that influence adult neurogenesis as potential therapy [J].
Shohayeb, Belal ;
Diab, Mohamed ;
Ahmed, Mazen ;
Dominic Chi Hiung Ng .
TRANSLATIONAL NEURODEGENERATION, 2018, 7
[14]   Microglial activation - tuning and pruning adult neurogenesis [J].
Ekdahl, Christine T. .
FRONTIERS IN PHARMACOLOGY, 2012, 3
[15]   SR-FTIR Biomolecular Characterization of the Hippocampus: The Role of Tenascin C in Adult Murine Neurogenesis in the Subgranular Zone [J].
Korenic, Milena ;
Korenic, Andrej ;
Stamenkovic, Vera ;
Ducic, Tanja ;
Andjus, Pavle .
CELLS, 2025, 14 (06)
[16]   Transcriptional control of glutamatergic differentiation during adult neurogenesis [J].
Hodge, Rebecca D. ;
Kahoud, Robert J. ;
Hevner, Robert F. .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (13) :2125-2134
[17]   Detrimental role of prolonged sleep deprivation on adult neurogenesis [J].
Femandes, Carina ;
Rocha, Nuno Barbosa F. ;
Rocha, Susana ;
Herrera-Solis, Andrea ;
Salas-Pacheco, Jose ;
Garcia-Garcia, Fabio ;
Murillo-Rodriguez, Eric ;
Yuan, Ti-Fei ;
Machado, Sergio ;
Arias-Carrion, Oscar .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2015, 9
[18]   Neurogenesis in the adult olfactory bulb [J].
Angela Pignatelli ;
Cristina Gambardella ;
Ottorino Belluzzi .
Neural Regeneration Research, 2011, 6 (08) :575-600
[19]   Neurogenesis in the adult olfactory bulb [J].
Pignatelli, Angela ;
Gambardella, Cristina ;
Belluzzi, Ottorino .
NEURAL REGENERATION RESEARCH, 2011, 6 (08) :575-600
[20]   Adult neurogenesis and the olfactory system [J].
Whitman, Mary C. ;
Greer, Charles A. .
PROGRESS IN NEUROBIOLOGY, 2009, 89 (02) :162-175
12345