Visual estimation of the extent of myocardial hyperenhancement on late gadolinium-enhanced CMR in patients with hypertrophic cardiomyopathy

被引:15
作者
Doesch, Christina [1 ]
Huck, Sonia [1 ]
Boehm, Christoph K. [2 ]
Michaely, Henrik [2 ]
Fluechter, Stephan [1 ]
Haghi, Dariusch [1 ]
Dinter, Dietmar [2 ]
Borggrefe, Martin [1 ]
Papavassiliu, Theano [1 ]
机构
[1] Univ Heidelberg, Dept Med 1, Univ Med Ctr Mannheim, Med Fac Mannheim, D-68167 Mannheim, Germany
[2] Univ Heidelberg, Dept Clin Radiol & Nucl Med, Univ Med Ctr Mannheim, Med Fac Mannheim, D-68167 Mannheim, Germany
关键词
Hypertrophic cardiomyopathy; Cardiovascular magnetic resonance; Planimetry; semiquantitative score; CARDIOVASCULAR MAGNETIC-RESONANCE; CONTRAST ENHANCEMENT; DELAYED ENHANCEMENT; INFARCT SIZE; Q-WAVE; MRI; VIABILITY; DYSFUNCTION; IMPROVEMENT; DEFINITION;
D O I
10.1016/j.mri.2010.03.034
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Aim: So far different approaches have been used to quantify late gadolinium enhancement (LGE) in patients with hypertrophic cardiomyopathy (HCM), but there is no general consensus on the gold standard, since histological data are scarce. The aim of our study was to investigate whether the determination of LGE in patients with HCM using a semiquantitative score based on the 17-segment model is feasible and has comparable accuracy to manual planimetry. Methods: Forty-two patients with HCM underwent LGE cardiovascular magnetic resonance imaging. Determination of LGE by planimetry based on visual assessment was used as reference standard. Then the extent of LGE was assessed using a semiquantitative score based on the standard left ventricular 17-segment model. Each segment was scored for the distribution of LGE. The resulting summed score expressed as percentage of the maximum possible score was thereafter compared with the manual planimetric evaluation of LGE, expressed as a percentage of the left ventricular myocardial area. Results: In 28 patients (66%), LGE was present. There was a good correlation between the semiquantitative score and the planimetric approach (r=0.89; y=0.819x+2.45; standard error of estimation=2.327; P<.0001). Additionally, the Bland-Altmann plot showed a high concordance between the two approaches (mean of the difference +1.7%). The inter- and intraobserver limits of agreement and the coefficients of repeatability based on measurements with the semiquantitative score of the extent of LGE were superior to planimetric measurements. Besides, the time requirement for the LGE determination using the semiquantitative score was found to be significantly reduced compared to manual planimetry (median 2 vs. 10 min). Conclusions: Thus, a reliable global index of the size of the LGE is feasible and can easily be obtained from visual assessment with a semiquantitative score of the extent of the hyperenhancement. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:812 / 819
页数:8
相关论文
共 26 条
[1]   Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy on relation to delayed enhancement on cardiovascular magnetic resonance [J].
Adabag, A. Selcuk ;
Maron, Barry J. ;
Appelbaum, Evan ;
Harrigan, Caltlin J. ;
Buros, Jacqueline L. ;
Gibson, C. Michael ;
Lesser, John R. ;
Hanna, Constance A. ;
Udelson, James E. ;
Manning, Warren J. ;
Maron, Martin S. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (14) :1369-1374
[2]   Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model [J].
Amado, LC ;
Gerber, BL ;
Gupta, SN ;
Szarf, G ;
Schock, R ;
Nasir, K ;
Kraitchman, DL ;
Lima, JAC .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2004, 44 (12) :2383-2389
[3]   Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction [J].
Beek, AM ;
Kühl, HP ;
Bondarenko, O ;
Twisk, JWR ;
Hofman, MBM ;
van Dockum, WG ;
Visser, CA ;
van Rossum, AC .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2003, 42 (05) :895-901
[4]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[5]   Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR [J].
Bondarenko, O ;
Beek, AM ;
Hofman, MBM ;
Kühl, HP ;
Twisk, JWR ;
van Dockum, WG ;
Visser, CA ;
van Rossum, AC .
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2005, 7 (02) :481-485
[6]   Time course of functional recovery after revascularization of hibernating myocardium: a contrast-enhanced cardiovascular magnetic resonance study [J].
Bondarenko, Olga ;
Beek, Aernout M. ;
Twisk, Jos W. R. ;
Visser, Cees A. ;
van Rossum, Albert C. .
EUROPEAN HEART JOURNAL, 2008, 29 (16) :2000-2005
[7]   Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart - A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association [J].
Cerqueira, MD ;
Weissman, NJ ;
Dilsizian, V ;
Jacobs, AK ;
Kaul, S ;
Laskey, WK ;
Pennell, DJ ;
Rumberger, JA ;
Ryan, T ;
Verani, MS .
CIRCULATION, 2002, 105 (04) :539-542
[8]   Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy [J].
Choudhury, L ;
Mahrholdt, H ;
Wagner, A ;
Choi, KM ;
Elliott, MD ;
Klocke, FJ ;
Bonow, RO ;
Judd, RM ;
Kim, RJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (12) :2156-2164
[9]   Visual estimation of the global myocardial extent of hyperenhancement on delayed contrast-enhanced MRI [J].
Comte, A ;
Lalande, A ;
Walker, PM ;
Cochet, A ;
Legrand, L ;
Cottin, Y ;
Wolf, JE ;
Brunotte, F .
EUROPEAN RADIOLOGY, 2004, 14 (12) :2182-2187
[10]   Accuracy of contrast-enhanced magnetic resonance imaging in predicting improvement of regional myocardial function in patients after acute myocardial infarction [J].
Gerber, BL ;
Garot, J ;
Bluemke, DA ;
Wu, KC ;
Lima, JAC .
CIRCULATION, 2002, 106 (09) :1083-1089