Characterization of a novel AAV capsid with enhanced brain transduction following systemic delivery

被引：0
|
作者：
Glenn, J. D. [1 ]
Yost, S. [1 ]
Firnberg, E. [1 ]
Mercer, A. [1 ]
Liu, Y. [1 ]
Coruzzi, L. [1 ]
Danos, O. [1 ]
Bruder, J. T. [1 ]
Karumuthil-Melethil, S. [1 ]
机构：
[1] ReGenX Biosci, Rockville, MD USA
来源：
HUMAN GENE THERAPY | 2019年 / 30卷 / 11期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
P011
引用
收藏
页码：A22 / A22
页数：1
相关论文
共 50 条
  • [21] CD47 Minipeptide Modification Paradoxically Enhances Anti-AAV Capsid Humoral Immunity Following Systemic Delivery
    Nance, Michael E.
    Yue, Yongping
    Shi, Ruicheng
    Million, Emily
    Discher, Dennis
    Duan, Dongsheng
    MOLECULAR THERAPY, 2020, 28 (04) : 186 - 186
  • [22] Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque
    Boye, Sanford L.
    Choudhury, Shreyasi
    Marsic, Damien
    Strang, Christianne E.
    Alexander, John J.
    Witherspoon, C. Douglas
    Zolotukhin, Sergei
    Gamlin, Paul D.
    Boye, Shannon Elizabeth
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [23] Correction: Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse
    Janine A. Gilkes
    Benjamin L. Judkins
    Brontie N. Herrera
    Ronald J. Mandel
    Sanford L. Boye
    Shannon E. Boye
    Arun Srivastava
    Coy D. Heldermon
    Gene Therapy, 2023, 30 : 736 - 736
  • [24] Rationally Designed a Novel AAV Capsid for Intra-Articular Gene Delivery
    Luo, Shuang
    Xie, Qing
    Li, Qingwei
    Zheng, Qiang
    MOLECULAR THERAPY, 2024, 32 (04) : 263 - 263
  • [25] Peptide Grafting Yields Novel AAV Vectors Capable of Enhanced Neuronal Transduction in Adult Mouse Brain
    Choudhury, Sourav
    Jones, Lindsay
    Maitland, Stacy
    Sena-Esteves, Miguel
    MOLECULAR THERAPY, 2014, 22 : S109 - S110
  • [26] Characterization of Novel Human-Derived AAV2 Variants with Brain Transduction Profiles that are Comparable to AAV9
    Xu, Meiyu
    Brown, Alexander
    Luo, Li
    Xu, Guangchao
    Qin, Wanru
    Xiao, Yuanyuan
    Wang, Chunmei
    Li, Jia
    Ma, Hong
    He, Ran
    Su, Qin
    Wei, Yuquan
    Tai, Phillip W. L.
    Gao, Guangping
    MOLECULAR THERAPY, 2019, 27 (04) : 89 - 90
  • [27] Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies
    Salabarria, Stephanie M.
    Corti, Manuela
    Coleman, Kirsten E.
    Wichman, Megan B.
    Berthy, Julie A.
    D'Souza, Precilla
    Tifft, Cynthia J.
    Herzog, Roland W.
    Elder, Melissa E.
    Shoemaker, Lawrence R.
    Leon-Astudillo, Carmen
    Tavakkoli, Fatemeh
    Kirn, David H.
    Schwartz, Jonathan D.
    Byrne, Barry J.
    JOURNAL OF CLINICAL INVESTIGATION, 2024, 134 (01)
  • [28] Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery
    Trevor J. Gonzalez
    Aaron Mitchell-Dick
    Leo O. Blondel
    Marco M. Fanous
    Joshua A. Hull
    Daniel K. Oh
    Sven Moller-Tank
    Ruth M. Castellanos Rivera
    Jorge A. Piedrahita
    Aravind Asokan
    Nature Protocols, 2023, 18 : 3413 - 3459
  • [29] Structure-guided AAV capsid evolution strategies for enhanced CNS gene delivery
    Gonzalez, Trevor J.
    Mitchell-Dick, Aaron
    Blondel, Leo O.
    Fanous, Marco M.
    Hull, Joshua A.
    Oh, Daniel K.
    Moller-Tank, Sven
    Rivera, Ruth M. Castellanos
    Piedrahita, Jorge A.
    Asokan, Aravind
    NATURE PROTOCOLS, 2023, 18 (11) : 3413 - +
  • [30] Enteric Nervous System Transduction Following IV Delivery of Multiple AAV Serotypes
    Lampe, Sara Gombash
    Cowley, Christopher
    Fitzgerald, Julie
    Mueller, Christian
    Christofi, Fedias
    Foust, Kevin
    FASEB JOURNAL, 2015, 29
12345