Primitive Endoderm Differentiation: From Specification to Epithelialization

被引:25
作者
Bassalert, Cecilia [1 ]
Valverde-Estrella, Lorena [1 ]
Chazaud, Claire [1 ]
机构
[1] Univ Clermont Auvergne, INSERM, CNRS, GReD, Clermont Ferrand, France
来源
CELL FATE IN MAMMALIAN DEVELOPMENT | 2018年 / 128卷
关键词
INNER CELL MASS; GENE-EXPRESSION; MOUSE EMBRYO; STEM-CELLS; XEN CELLS; PROMOTES DIFFERENTIATION; LINEAGE SEGREGATION; DYNAMIC EXPRESSION; VISCERAL ENDODERM; PARIETAL ENDODERM;
D O I
10.1016/bs.ctdb.2017.12.001
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
At the time of implantation, the mouse blastocyst has developed three cell lineages: the epiblast (Epi), the primitive endoderm (PrE), and the trophectoderm (TE). The PrE and TE are extraembryonic tissues but their interactions with the Epi are critical to sustain embryonic growth, as well as to pattern the embryo. We review here the cellular and molecular events that lead to the production of PrE and Epi lineages and discuss the different hypotheses that are proposed for the induction of these cell types. In the second part, we report the current knowledge about the epithelialization of the PrE.
引用
收藏
页码:81 / 104
页数:24
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