Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

被引：9

作者：

Hawkins, Clare L. ^{[1
,2
]}

机构：

[1] Heart Res Inst, Newtown, NSW 2042, Australia

[2] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

来源：

KIDNEY INTERNATIONAL | 2014年 / 86卷 / 05期

关键词：

CHRONIC-RENAL-FAILURE; LDL;

D O I：

10.1038/ki.2014.256

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cyanate is a uremic toxin responsible for the carbamylation of proteins, which has been implicated as playing a key role in accelerating the progression of atherosclerosis in patients with chronic kidney disease. El-Gamal et al. report that while cyanate promotes protein carbamylation in vivo, the resulting endothelial dysfunction observed is consistent with reactions mediated by cyanate itself, rather than by carbamylated proteins. This provides new insight into the relationship between uremia and cardiovascular disease.

引用

页码：875 / 877

页数：3

共 10 条

[1] Quantification of carbamylated LDL in human sera by a new sandwich ELISA [J].

Apostolov, EO ;

Shah, SV ;

Ok, E ;

Basnakian, AG .

CLINICAL CHEMISTRY, 2005, 51 (04) :719-728

[2] Carbamylated low-density lipoprotein induces monocyte adhesion to endothelial cells through intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 [J].

Apostolov, Eugene O. ;

Shah, Sudhir V. ;

Ok, Ercan ;

Basnakian, Alexei G. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (04) :826-832

[3] CARBAMYLATED LDL [J].

Basnakian, Alexei G. ;

Shah, Sudhir V. ;

Ok, Ercan ;

Altunel, Ekrem ;

Apostolov, Eugene O. .

ADVANCES IN CLINICAL CHEMISTRY, VOL 51, 2010, 51 :25-52

[4] The urea decomposition product cyanate promotes endothelial dysfunction [J].

El-Gamal, Dalia ;

Rao, Shailaja P. ;

Holzer, Michael ;

Hallstroem, Seth ;

Haybaeck, Johannes ;

Gauster, Martin ;

Wadsack, Christian ;

Kozina, Andrijana ;

Frank, Sasa ;

Schicho, Rudolf ;

Schuligoi, Rufina ;

Heinemann, Akos ;

Marsche, Gunther .

KIDNEY INTERNATIONAL, 2014, 86 (05) :923-931

[5] Cyanate Is a Novel Inducer of Endothelial ICAM-1 Expression [J].

El-Gamal, Dalia ;

Holzer, Michael ;

Gauster, Martin ;

Schicho, Rudolf ;

Binder, Veronika ;

Konya, Viktoria ;

Wadsack, Christian ;

Schuligoi, Rufina ;

Heinemann, Akos ;

Marsche, Gunther .

ANTIOXIDANTS & REDOX SIGNALING, 2012, 16 (02) :129-137

[6] Carbamylation-Derived Products: Bioactive Compounds and Potential Biomarkers in Chronic Renal Failure and Atherosclerosis [J].

Jaisson, Stephane ;

Pietrement, Christine ;

Gillery, Philippe .

CLINICAL CHEMISTRY, 2011, 57 (11) :1499-1505

[7] Protein Carbamylation Predicts Mortality in ESRD [J].

Koeth, Robert A. ;

Kalantar-Zadeh, Kamyar ;

Wang, Zeneng ;

Fu, Xiaoming ;

Tang, W. H. Wilson ;

Hazen, Stanley L. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2013, 24 (05) :853-861

[8]

Nilsson L, 1996, CLIN CHEM, V42, P482

[9] Impaired thrombolysis: a novel cardiovascular risk factor in end-stage renal disease [J].

Sharma, Sumeet ;

Farrington, Ken ;

Kozarski, Robert ;

Christopoulos, Christos ;

Niespialowska-Steuden, Maria ;

Moffat, Daniel ;

Gorog, Diana A. .

EUROPEAN HEART JOURNAL, 2013, 34 (05) :354-+

[10] Protein carbamylation links inflammation, smoking, uremia and atherogenesis [J].

Wang, Zeneng ;

Nicholls, Stephen J. ;

Rodriguez, E. Rene ;

Kummu, Outi ;

Horkko, Sohvi ;

Barnard, John ;

Reynolds, Wanda F. ;

Topol, Eric J. ;

DiDonato, Joseph A. ;

Hazen, Stanley L. .

NATURE MEDICINE, 2007, 13 (10) :1176-1184

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