Electrical devices for visual restoration

被引：6

作者：

Sharf, Tamara ^{[1
]}

Kalakuntla, Tej ^{[1
]}

Lee, Darrin J. ^{[2
]}

Gokoffski, Kimberly K. ^{[3
,4
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[2] Univ Southern Calif, Dept Neurol Surg, Los Angeles, CA USA

[3] Univ Southern Calif, Roski Eye Inst, Dept Ophthalmol, Los Angeles, CA USA

[4] Univ Southern Calif, Roski Eye Inst, Dept Ophthalmol, 1450 San Pablo St 4th Floor, Los Angeles, CA 90033 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2022年 / 67卷 / 03期

关键词：

electrical stimulation; visual prosthesis; vision restoration; axon regeneration; neuromodulation; DEEP BRAIN-STIMULATION; II RETINAL PROSTHESIS; OPTIC-NERVE; ARTIFICIAL VISION; AXON REGENERATION; NEURITE GROWTH; GANGLION-CELLS; BLIND; PERCEPTION; NUCLEUS;

D O I：

10.1016/j.survophthal.2021.08.008

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Given the rising number of patients with blindness from macular, optic nerve, and visual pathway disease, there is considerable interest in the potential of electrical stimulation devices to restore vision. Electrical devices for restoration of visual function can be grouped into three categories: (1) visual prostheses whose goal is to bypass damaged areas and directly activate downstream intact portions of the visual pathway; (2) electric field stimulation whose goal is to activate endogenous transcriptional and molecular signaling pathways to promote neuroprotection and neuro-regeneration; and (3) neuromodulation whose stimulation would resuscitate neural circuits vital to coordinating responses to visual input. In this review, we discuss these three approaches, describe advances made in the different fields, and comment on limitations and potential future directions. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：793 / 800

页数：8

共 62 条

[1] Electrical stimulation accelerates and increases expression of BDNF and trkB rnRNA in regenerating rat femoral motoneurons [J].