Circulating Tumor Cells for Glioma

被引:25
作者
Zhang, Huikai [1 ]
Yuan, Fanen [1 ]
Qi, Yangzhi [1 ]
Liu, Baohui [1 ]
Chen, Qianxue [1 ]
机构
[1] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
glioma; circulating tumor cells; liquid biopsy; blood; biomarker; FIBRILLARY ACIDIC PROTEIN; BRAIN METASTASES; CANCER; GLIOBLASTOMA; ANEUPLOIDY; EXPRESSION; SURVIVAL; EGFR; ASSOCIATION; EXOSOMES;
D O I
10.3389/fonc.2021.607150
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Liquid biopsy has entered clinical applications for several cancers, including metastatic breast, prostate, and colorectal cancer for CTC enumeration and NSCLC for EGFR mutations in ctDNA, and has improved the individualized treatment of many cancers, but relatively little progress has been made in validating circulating biomarkers for brain malignancies. So far, data on circulating tumor cells about glioma are limited, the application of circulating tumor cells as biomarker for glioma patients has only just begun. This article reviews the research status and application prospects of circulating tumor cells in gliomas. Several detection methods and research results of circulating tumor cells about clinical research in gliomas are briefly discussed. The wide application prospect of circulating tumor cells in glioma deserves further exploration, and the research on more sensitive and convenient detection methods is necessary.
引用
收藏
页数:9
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