In this paper, we shall consider the existence and uniqueness of solutions to neutral stochastic functional differential equations with infinite delay in L-p(Omega,C-h) space: d[x(t) G(x(t))] = f(t, x(t))dt + g(t, x(t))dB(t), where we assume f : R+ x L-p(Omega,C-h) -> L-p (Omega, R-n), g : R+ x L-p(Omega,C-h) -> L-p (Omega, L(R-m, R-n)), G : Lp (Omega, C-h) -> L-p(Omega, R-n), p> 2, and B(t) is a given m-dimensional Brownian motion.