Evolution of isotype switching

被引：127
作者：
Stavnezer, J
Amemiya, CT
机构：
[1] Univ Massachusetts, Sch Med, Dept Mol Genet & Microbiol, Program Immunol & Virol, Worcester, MA 01655 USA
[2] Benaroya Res Inst Virginia Mason, Dept Mol Genet, Seattle, WA 98101 USA
[3] Univ Washington, Dept Biol, Seattle, WA 98195 USA
来源：
SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 04期
关键词：
immunoglobulins; antibody class switch recombination; somatic hypermutation; AID; IgH gene loci;
D O I：
10.1016/j.smim.2004.08.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This review discusses evolution of the process of Ig heavy chain class switching, relating it to the first appearance of somatic hypermutation (SHM) of variable region genes. First, we discuss recent findings on the mechanism of class switch recombination (CSR) in mice and humans, and then review the mechanisms of expression of Ig heavy chain isotypes from fishes to mammals. Importantly, activation-induced cytidine deaminase (AID), which is essential for CSR and somatic hypermutation, is found in fishes. Although at least some fishes are likely to undergo SHM, CSR is highly unlikely to occur in this group. We discuss the first appearance of CSR in amphibians and how it differs in birds and mammals. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：257 / 275
页数：19
相关论文
共 213 条
[1]   COMPLETE NUCLEOTIDE-SEQUENCE OF AN IMMUNOGLOBULIN HEAVY-CHAIN GENE AND ANALYSIS OF IMMUNOGLOBULIN GENE ORGANIZATION IN A PRIMITIVE TELEOST SPECIES [J].
AMEMIYA, CT ;
LITMAN, GW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) :811-815
[2]   V(H)GENE ORGANIZATION IN A RELICT SPECIES, THE COELACANTH LATIMERIA-CHALUMNAE - EVOLUTIONARY IMPLICATIONS [J].
AMEMIYA, CT ;
OHTA, Y ;
LITMAN, RT ;
RAST, JP ;
HAIRE, RN ;
LITMAN, GW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6661-6665
[3]  
AMEMIYA CT, 1996, CURRENT TOPICS MOL E, V1, P159
[4]   COMPLETE GENOMIC SEQUENCE AND PATTERNS OF TRANSCRIPTION OF A MEMBER OF AN UNUSUAL FAMILY OF CLOSELY-RELATED, CHROMOSOMALLY DISPERSED IG GENE CLUSTERS IN RAJA [J].
ANDERSON, M ;
AMEMIYA, C ;
LUER, C ;
LITMAN, R ;
RAST, J ;
NIIMURA, Y ;
LITMAN, G .
INTERNATIONAL IMMUNOLOGY, 1994, 6 (11) :1661-1670
[5]   A long form of the skate IgX gene exhibits a striking resemblance to the new shark IgW and IgNARC genes [J].
Anderson, MK ;
Strong, SJ ;
Litman, RT ;
Luer, CA ;
Amemiya, CT ;
Rast, JP ;
Litman, GW .
IMMUNOGENETICS, 1999, 49 (01) :56-67
[6]  
[Anonymous], 1990, IMMUNE SYSTEM COMP H
[7]   Immunoglobulin gene hyperconversion ongoing in chicken splenic germinal centers [J].
Arakawa, H ;
Furusawa, S ;
Ekino, S ;
Yamagishi, H .
EMBO JOURNAL, 1996, 15 (10) :2540-2546
[8]   Cloning and structural analysis of IgM (μ chain) and the heavy chain V region repertoire in the marsupial Monodelphis domestica [J].
Aveskogh, M ;
Pilström, L ;
Hellman, L .
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1999, 23 (7-8) :597-606
[9]  
Aveskogh M, 1998, EUR J IMMUNOL, V28, P2738, DOI 10.1002/(SICI)1521-4141(199809)28:09<2738::AID-IMMU2738>3.0.CO
[10]  
2-I
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