Systems biology based metabolic engineering for non-natural chemicals

被引：35

作者：

Biz, Alessandra ^{[1
]}

Proulx, Scott ^{[1
]}

Xu, Zhiqing ^{[1
]}

Siddartha, Kavya ^{[1
]}

Indrayanti, Alex Mulet ^{[1
]}

Mahadevan, Radhakrishnan ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Toronto, ON, Canada

来源：

BIOTECHNOLOGY ADVANCES | 2019年 / 37卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Stems biology; Non-natural chemicals; In-silico pathway design; Directed evolution; de novo protein engineering; Genome-scale models; Flux balance analysis; Dynamic control; Growth-coupled production; Orthogonality; DYNAMIC PATHWAY REGULATION; MUCONIC ACID PRODUCTION; ESCHERICHIA-COLI; MICROBIAL-PRODUCTION; COMPUTATIONAL DESIGN; BIOCHEMICAL REACTIONS; STRAIN OPTIMIZATION; DIRECTED EVOLUTION; RATIONAL DESIGN; GENE-EXPRESSION;

D O I：

10.1016/j.biotechadv.2019.04.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Production of chemicals in microorganisms is no longer restricted to products arising from native metabolic potential. In this review, we highlight the evolution of metabolic engineering studies, from the production of natural chemicals fermented from biomass hydrolysates, to the engineering of microorganisms for the production of non-natural chemicals. Advances in synthetic biology are accelerating the successful development of microbial cell factories to directly produce value-added chemicals. Here we outline the emergence of novel computational tools for the creation of synthetic pathways, for designing artificial enzymes for non-natural reactions and for re-wiring host metabolism to increase the metabolic flux to products. We also highlight exciting opportunities for applying directed evolution of enzymes, dynamic control of growth and production, growth coupling strategies as well as decoupled strategies based on orthogonal pathways in the context of non-natural chemicals.

引用

页数：20

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