A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin

被引：109

作者：

Hamuro, Koji ^{[1
]}

Suetake, Hiroaki ^{[1
]}

Saha, Nil Ratan ^{[1
]}

Kikuchi, Kiyoshi ^{[1
]}

Suzuki, Yuzuru ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Fisheries Lab, Hamamatsu, Shizuoka, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2007年 / 178卷 / 09期

关键词：

D O I：

10.4049/jimmunol.178.9.5682

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The skin mucus IgM is an important molecule in the mucosal immune system of teleost skin. However, the transport mechanism associated with this molecule has yet to be clarified. In this study, we isolated a gene encoding a polymeric Ig receptor (pIgR) from a species of teleost fish, Takifugu rubripes (fugu). This gene is known to be an Ig transporter in the intestine of mammals. Our studies further demonstrated that fugu pIgR was expressed in the skin and that a fragment of pIgR bound to tetrameric IgM in the skin mucus. These results indicate that the skin pIgR transports tetrameric IgM into the skin mucus. The fugu pIgR exhibits a unique structure containing only two Ig-like domains corresponding to domain I and domain 415 of mammalian pIgR. This structure was sufficient for successful binding to tetrameric IgM. Teleost skin thus adopts the same Ig transport system as mammalian intestine via a unique pIgR. The Journal of Immunology, 2007, 178: 5682-5689.

引用

页码：5682 / 5689

页数：8

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