Application of microbial lipases to concentrate polyunsaturated fatty acids.

被引：34

作者：

Carvalho, PD ^{[1
]}

Campos, PRB ^{[1
]}

Noffs, MD ^{[1
]}

de Oliveira, JG ^{[1
]}

Shimizu, MT ^{[1
]}

da Silva, DM ^{[1
]}

机构：

[1] Univ Sao Francisco, Curso Farmacia, Ctr Ciencias Biol & Saude, BR-12916900 Braganca Paulista, SP, Brazil

来源：

QUIMICA NOVA | 2003年 / 26卷 / 01期

关键词：

polyunsaturated fatty acid; lipase; fatty acid selectivity;

D O I：

10.1590/S0100-40422003000100014

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several polyunsaturated fatty acids (PUFA) belonging to the omega 6 series, such as cis-6,9,12 gamma-linolenic acid, as well as those of the omega 3 series, such as cis-5,8,1 1,14,17-eicosapentaenoic acid and cis-4,7,10,13,16,19-docosahexaenoic acid are of considerable interest due to their nutritional and therapeutic properties. Methods used for the concentration of PUFA from natural sources include men adduct formation, solvent winterization, supercritical fluid extraction and lipase-catalyzed reaction. Lipases are known to have little reactivity on PUFA and these acids can be enriched by selective hydrolysis, direct esterification of glycerol with PUFA and interesterification. Since lipase reactions are advantageous with respect to fatty acid, positional specificities and mild incubation condition, these enzymes are considered to be suitable for the production of PUFA concentrates for medical purposes.

引用

页码：75 / 80

页数：6

共 77 条

[31] The role of dietary n-6 and n-3 fatty acids in the developing brain [J].

Innis, SM .

DEVELOPMENTAL NEUROSCIENCE, 2000, 22 (5-6) :474-480

[32] TREATMENT OF DIABETIC NEUROPATHY WITH GAMMA-LINOLENIC ACID [J].

KEEN, H ;

PAYAN, J ;

ALLAWI, J ;

WALKER, J ;

JAMAL, GA ;

WEIR, AI ;

HENDERSON, LM ;

BISSESSAR, EA ;

WATKINS, PJ ;

SAMPSON, M ;

GALE, EAM ;

SCARPELLO, J ;

BODDIE, HG ;

HARDY, KJ ;

THOMAS, PK ;

MISRA, P ;

HALONEN, JP .

DIABETES CARE, 1993, 16 (01) :8-15

[33]

Kinsella J E, 1991, Adv Food Nutr Res, V35, P1, DOI 10.1016/S1043-4526(08)60064-9

[34] FISH-OIL FATTY-ACID SUPPLEMENTATION IN ACTIVE RHEUMATOID-ARTHRITIS - A DOUBLE-BLINDED, CONTROLLED, CROSSOVER STUDY [J].

KREMER, JM ;

JUBIZ, W ;

MICHALEK, A ;

RYNES, RI ;

BARTHOLOMEW, LE ;

BIGAOUETTE, J ;

TIMCHALK, M ;

BEELER, D ;

LININGER, L .

ANNALS OF INTERNAL MEDICINE, 1987, 106 (04) :497-503

[35]

LANDS WEM, 1986, NUTR REV, V44, P189, DOI 10.1111/j.1753-4887.1986.tb07625.x

[36]

LI ZY, 1993, BIOTECHNOL LETT, V15, P185, DOI 10.1007/BF00133021

[37]

LI ZY, 1993, BIOTECHNOL LETT, V15, P393, DOI 10.1007/BF00128283

[38] LIPASE-CATALYZED ESTERIFICATION OF GLYCEROL AND N-3 POLYUNSATURATED FATTY-ACID CONCENTRATE IN ORGANIC-SOLVENT [J].

LI, ZY ;

WARD, OP .

JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY, 1993, 70 (08) :745-748

[39]

LIE E, 1992, INT J FOOD SCI TECH, V27, P73

[40] PRESENT AND FUTURE APPLICATIONS OF LIPASES [J].

MACRAE, AR ;

HAMMOND, RC .

BIOTECHNOLOGY & GENETIC ENGINEERING REVIEWS, 1985, 3 :193-217

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