Biocompatibility of Fe3O4 nanoparticles evaluated by in vitro cytotoxicity assays using normal, glia and breast cancer cells

被引：235
作者：
Ankamwar, B. [1 ]
Lai, T. C. [2 ]
Huang, J. H. [1 ]
Liu, R. S. [1 ]
Hsiao, M. [2 ]
Chen, C. H. [2 ]
Hwu, Y. K. [3 ]
机构：
[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan
[2] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan
[3] Acad Sinica, Inst Phys, Taipei 115, Taiwan
来源：
NANOTECHNOLOGY | 2010年 / 21卷 / 07期
关键词：
IRON-OXIDE NANOPARTICLES; DRUG-DELIVERY; MAGNETITE NANOPARTICLES; CELLULAR UPTAKE; VIVO TRACKING; DEXTRAN; NANOTECHNOLOGY; HYPERTHERMIA; TOXICITY; SIZE;
D O I：
10.1088/0957-4484/21/7/075102
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In order to reveal the biocompatibility of Fe3O4 nanoparticles and bipolar surfactant tetramethylammonium 11-aminoundecanoate cytotoxicity tests were performed as a function of concentration from low (0.1 mu g ml(-1)) to higher concentration (100 mu g ml(-1)) using various human glia, human breast cancer and normal cell lines. Cytotoxicity tests for human glia (D54MG, G9T, SF126, U87, U251, U373), human breast cancer (MB157, SKBR3, T47D) and normal (H184B5F5/M10, WI-38, SVGp12) cell lines exhibited almost nontoxicity and reveal biocompatibility of Fe3O4 nanoparticles in the concentration range of 0.1-10 mu g ml(-1), while accountable cytotoxicity can be seen at 100 mu g ml(-1). The results of our studies suggest that Fe3O4 nanoparticles coated with bipolar surfactant tetramethylammonium 11-aminoundecanoate are biocompatible and promising for bio-applications such as drug delivery, magnetic resonance imaging and magnetic hyperthermia.
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页数：9
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共 41 条
[1]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[2]   Gold nanotriangles biologically synthesized using tamarind leaf extract and potential application in vapor sensing [J].
Ankamwar, B ;
Chaudhary, M ;
Sastry, M .
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2005, 35 (01) :19-26
[3]   Relation between the redox state of iron-based nanoparticles and their cytotoxicity toward Escherichia coli [J].
Auffan, Melanie ;
Achouak, Wafa ;
Rose, Jerome ;
Roncato, Marie-Anne ;
Chaneac, Corinne ;
Waite, David T. ;
Masion, Armand ;
Woicik, Joseph C. ;
Wiesner, Mark R. ;
Bottero, Jean-Yves .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (17) :6730-6735
[4]   Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro [J].
Berry, CC ;
Wells, S ;
Charles, S ;
Curtis, ASG .
BIOMATERIALS, 2003, 24 (25) :4551-4557
[5]   Luminescent quantum dots for multiplexed biological detection and imaging [J].
Chan, WCW ;
Maxwell, DJ ;
Gao, XH ;
Bailey, RE ;
Han, MY ;
Nie, SM .
CURRENT OPINION IN BIOTECHNOLOGY, 2002, 13 (01) :40-46
[6]   Toxicity of gold nanoparticles functionalized with cationic and anionic side chains [J].
Goodman, CM ;
McCusker, CD ;
Yilmaz, T ;
Rotello, VM .
BIOCONJUGATE CHEMISTRY, 2004, 15 (04) :897-900
[7]   In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications [J].
Greenhalgh, Kerriann ;
Turos, Edward .
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2009, 5 (01) :46-54
[8]   Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles [J].
Gupta, AK ;
Gupta, M .
BIOMATERIALS, 2005, 26 (13) :1565-1573
[9]   Surface-modified superparamagnetic nanoparticles for drug delivery: Preparation, characterization, and cytotoxicity studies [J].
Gupta, AK ;
Wells, S .
IEEE TRANSACTIONS ON NANOBIOSCIENCE, 2004, 3 (01) :66-73
[10]   Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].
Hirsch, LR ;
Stafford, RJ ;
Bankson, JA ;
Sershen, SR ;
Rivera, B ;
Price, RE ;
Hazle, JD ;
Halas, NJ ;
West, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554
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