The function of NOD-like receptors in central nervous system diseases

被引：30
作者：
Kong, Xiangxi [1 ,2 ]
Yuan, Zengqiang [1 ,3 ]
Cheng, Jinbo [1 ,3 ]
机构：
[1] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
[2] Lanzhou Univ, Sch Basic Med Sci, Lanzhou 730000, Gansu, Peoples R China
[3] Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100069, Peoples R China
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2017年 / 95卷 / 08期
关键词：
NOD-like receptors; innate immunity; neurodegeneration; neuroinflammation; inflammasome; NLRP3 INFLAMMASOME ACTIVATION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; TOLL-LIKE RECEPTORS; PARKINSONS-DISEASE; INNATE IMMUNITY; ALZHEIMERS-DISEASE; AMYLOID-BETA; NALP3; INFLAMMASOME;
D O I：
10.1002/jnr.24004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and autoimmune disorders. Recent studies have indicated that the proteins of the NLR family are linked with the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), and psychological diseases. In this review, we mainly focus on the role of NLRs and the underlying signaling pathways in central nervous system (CNS) diseases. (c) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：1565 / 1573
页数：9
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