Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein

被引：9
作者：
Hamalainen, Sari [1 ]
Juutilainen, Auni [1 ,2 ]
Kuittinen, Taru [1 ]
Nousiainen, Tapio [1 ]
Matinlauri, Irma [3 ]
Pulkki, Kari [4 ,5 ]
Koivula, Irma [1 ]
Jantunen, Esa [1 ,2 ]
机构：
[1] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland
[2] Univ Eastern Finland, Inst Clin Med Internal Med, Kuopio, Finland
[3] Turku Univ, Cent Hosp, Dept Clin Chem, Turku, Finland
[4] Univ Eastern Finland, Eastern Finland Lab Ctr, Kuopio, Finland
[5] Univ Eastern Finland, Dept Clin Chem, Kuopio, Finland
来源：
LEUKEMIA & LYMPHOMA | 2010年 / 51卷 / 06期
关键词：
N-terminal pro-BNP; C-reactive protein; neutropenic fever; severe sepsis; hematological patients; CRITICALLY-ILL PATIENTS; SEVERE SEPSIS; SEPTIC SHOCK; FEBRILE NEUTROPENIA; PROGNOSTIC VALUE; BNP; DEFINITIONS; DYSFUNCTION; GUIDELINES; FAILURE;
D O I：
10.3109/10428191003743478
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Serum amino-terminal pro-brain natriuretic peptide (NT-proBNP) is considered as a prognostic marker in patients with severe sepsis or septic shock, but no data are available on NT-proBNP kinetics in hematological patients with neutropenic fever. Altogether 70 hematological patients with neutropenic fever were included in this prospective study. NT-proBNP and C-reactive protein (CRP) were determined at the beginning of the neutropenic fever (d0) and then daily up to 3-4 days. The median NT-proBNP (interquartile range) increased from 127 (57-393) ng/L on d0 to 542 (194-1385) ng/L on d4. The increment of CRP was from 35 (17-61) mg/L on d0 to 109 (56-109) mg/L on d2. Neither serial NT-proBNP nor CRP predicted development of severe sepsis, but NT-proBNP was significantly higher in patients with previous cardiovascular disease than in those without. NT-proBNP seemed to reflect cardiac distress, but it did not help to predict the development of severe sepsis in this patient group.
引用
收藏
页码：1040 / 1046
页数：7
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