"YOU CAN'T ALWAYS GET WHAT YOU WANT" - LINEARITY AS THE GOLDEN RATIO OF TOXICOLOGY

被引：0
作者：
Bast, Aalt [1 ]
Hanekamp, Jaap C. [2 ,3 ]
机构：
[1] Maastricht Univ, Dept Toxicol, NL-6200 MD Maastricht, Netherlands
[2] Univ Coll Roosevelt, Middelburg, Netherlands
[3] Univ Massachusetts, Amherst, MA 01003 USA
来源：
DOSE-RESPONSE | 2014年 / 12卷 / 04期
关键词：
Golden Ratio; LNT; adaption; reification fallacy; SUPEROXIDE-DISMUTASE; DIETARY NITRATE;
D O I：
10.2203/dose-response.13-032.Hanekamp
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.
引用
收藏
页码：664 / 672
页数：9
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