Aortic atherosclerosis detected with electron-beam CT as a predictor of obstructive coronary artery disease

被引:44
作者
Takasu, J [1 ]
Mao, S [1 ]
Budoff, MJ [1 ]
机构
[1] Univ Calif Los Angeles, Harbor Med Ctr, Res & Educ Inst, Div Cardiol, Torrance, CA 90502 USA
关键词
aorta; arteriosclerosis; CT; computed tomography (CT); electron beam; coronary vessels; calcification; diseases;
D O I
10.1016/S1076-6332(03)80081-8
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Rationale and Objectives. Several studies have demonstrated an association between coronary and aortic atherosclerosis. Aortic atherosclerosis is easily quantified by means of electron-beam computed tomography (CT). The aim of this study was to evaluate the usefulness of measurement of aortic atherosclerosis with electron-beam CT as an independent predictor of obstructive coronary artery disease (CAD). Materials and Methods. Ninety-seven patients (67 men, 30 women; mean age, 61 years +/- 12) were enrolled and underwent electron-beam CT with and without contrast material. Coronary artery calcification was quantified with nonenhanced electron-beam CT by means of Agatston score. CAD was defined as luminal narrowing of the coronary artery by at least 70%, as measured with electron-beam angiography. Aortic atherosclerosis was quantified by measuring raised lesions of the aortic wall (plaque) and wall thickening (volume and thickness) in the midportion of the descending thoracic aorta (10 contiguous sections), as depicted at contrast material-enhanced CT angiography. Results. Aortic plaque and calcification were detected only in patients who were at least 58 years old. The presence of aortic plaque was predictive of obstructive CAD, independent of coronary artery calcification. The sensitivity of aortic plaque (raised lesions) for obstructive CAD was 89% in patients at least 58 years old, and the specificity was 63%. Aortic calcification had a sensitivity of 56% and a specificity of 72% for diagnosis of obstructive CAD. Conclusion. This study demonstrated that aortic plaque detected with contrast-enhanced electron-beam CT was a more consistent predictor of obstructive CAD than other independent aortic variables. Aortic calcification depicted on nonenhanced CT images was highly specific for obstructive CAD. (C) AUR, 2003.
引用
收藏
页码:631 / 637
页数:7
相关论文
共 31 条
[1]   Contrast enhanced electron beam computed tomography to analyse the coronary arteries in patients after acute myocardial infarction [J].
Achenbach, S ;
Ropers, D ;
Regenfus, M ;
Muschiol, G ;
Daniel, WG ;
Moshage, W .
HEART, 2000, 84 (05) :489-493
[2]   Value of electron-beam computed tomography for the noninvasive detection of high-grade coronary-artery stenoses and occlusions [J].
Achenbach, S ;
Moshage, W ;
Ropers, D ;
Nossen, J ;
Daniel, WG .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (27) :1964-1971
[3]   Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population [J].
Agmon, Y ;
Khandheria, BK ;
Meissner, I ;
Schwartz, GL ;
Petterson, TM ;
O'Fallon, WM ;
Whisnant, JP ;
Wiebers, DO ;
Seward, JB .
AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (03) :262-267
[4]   ANGIOGRAPHIC PROGRESSION OF CORONARY-ARTERY DISEASE AND THE DEVELOPMENT OF MYOCARDIAL-INFARCTION [J].
AMBROSE, JA ;
TANNENBAUM, MA ;
ALEXOPOULOS, D ;
HJEMDAHLMONSEN, CE ;
LEAVY, J ;
WEISS, M ;
BORRICO, S ;
GORLIN, R ;
FUSTER, V .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1988, 12 (01) :56-62
[5]   Geometric reconstruction for computational mesh generation of arterial bifurcations from CT angiography [J].
Antiga, L ;
Ene-Iordache, B ;
Caverni, L ;
Cornalba, GP ;
Remuzzi, A .
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2002, 26 (04) :227-235
[6]   Prediction of coronary events with electron beam computed tomography [J].
Arad, Y ;
Spadaro, LA ;
Goodman, K ;
Newstein, D ;
Guerci, AD .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (04) :1253-1260
[7]   AGE EFFECTS AND AUTOPSY EVIDENCE OF DISEASE IN FATALLY INJURED DRIVERS [J].
BAKER, SP ;
SPITZ, WU .
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1970, 214 (06) :1079-&
[8]   Preview method for electron-beam CT scanning of the coronary arteries [J].
Bakhsheshi, H ;
Mao, SS ;
Budoff, MJ ;
Bin, L ;
Brundage, BH .
ACADEMIC RADIOLOGY, 2000, 7 (08) :620-626
[9]   Evaluation of carotid artery and aortic intima-media thickness measurements for exclusion of significant coronary atherosclerosis in patients scheduled for heart valve surgery [J].
Belhassen, L ;
Carville, C ;
Pelle, G ;
Monin, JL ;
Teiger, E ;
Duval-Moulin, AM ;
Dupouy, P ;
Rande, JLD ;
Gueret, P .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (07) :1139-1144
[10]   CT angiography in the assessment of carotid artery atherosclerosis -: A comparative analysis with MR angiography with reference to contrast angiography and intravascular ultrasound [J].
Berg, MH ;
Manninen, HI ;
Räsänen, HT ;
Vanninen, RL ;
Jaakkola, PA .
ACTA RADIOLOGICA, 2002, 43 (02) :116-124