Differential modulation of nitric oxide production by curcumin in host macrophages and NK cells

被引：119

作者：

Bhaumik, S ^{[1
]}

Jyothi, MD ^{[1
]}

Khar, A ^{[1
]}

机构：

[1] Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

来源：

FEBS LETTERS | 2000年 / 483卷 / 01期

关键词：

nitric oxide; inducible nitric oxide synthase; macrophage; NK cell; tumor regression;

D O I：

10.1016/S0014-5793(00)02089-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Curcumin, the yellow pigment from Curcuma longa, has been shown to possess tumoricidal activity. We have earlier reported the induction of apoptosis in AK-5, rat histiocytic cells by curcumin leading to the inhibition of tumor growth in vivo. In this study me have observed differential activation status in host macrophages and NK cells induced by curcumin during the spontaneous regression of subcutaneously transplanted AK-5 tumors. Closer scrutiny of the cytokine profile and nitric oxide (NO) production by immune cells showed an initial downregulation of Th1 cytokine response and WO production by macrophages, and their upregulation in NK cells, which picked-up upon prolonged treatment with curcumin, culminating in a stronger tumoricidal effect. These studies suggest that the host macrophages and NK cells play an important modulatory role in the remission of AK-5 tumor. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：78 / 82

页数：5

共 28 条

[1] Induction of nitric oxide production by the peritoneal macrophages after intraperitoneal or subcutaneous transplantation of AK-5 tumor [J].

Bhaumik, S ;

Khar, A .

NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 1998, 2 (06) :467-474

[2] Cytokine-induced production of NO by macrophages induces apoptosis and immunological rejection of AK-5 histiocytic tumor [J].

Bhaumik, S ;

Khar, A .

APOPTOSIS, 1998, 3 (05) :361-368

[3] Curcumin mediated apoptosis in AK-5 tumor cells involves the production of reactive oxygen intermediates [J].

Bhaumik, S ;

Anjum, R ;

Rangaraj, N ;

Pardhasaradhi, BVV ;

Khar, A .

FEBS LETTERS, 1999, 456 (02) :311-314

[4] CURCUMIN, AN ANTITUMOR PROMOTER AND ANTIINFLAMMATORY AGENT, INHIBITS INDUCTION OF NITRIC-OXIDE SYNTHASE IN ACTIVATED MACROPHAGES [J].

BROUET, I ;

OHSHIMA, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 206 (02) :533-540

[5] INHIBITION OF TUMOR-NECROSIS-FACTOR BY CURCUMIN, A PHYTOCHEMICAL [J].

CHAN, MMY .

BIOCHEMICAL PHARMACOLOGY, 1995, 49 (11) :1551-1556

[6] In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties [J].

Chan, MMY ;

Huang, HI ;

Fenton, MR ;

Fong, D .

BIOCHEMICAL PHARMACOLOGY, 1998, 55 (12) :1955-1962

[7] Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells [J].

Chen, HW ;

Huang, HC .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 (06) :1029-1040

[8] ANALYSIS OF NITRATE, NITRITE, AND [N-15]-LABELED NITRATE IN BIOLOGICAL-FLUIDS [J].

GREEN, LC ;

WAGNER, DA ;

GLOGOWSKI, J ;

SKIPPER, PL ;

WISHNOK, JS ;

TANNENBAUM, SR .

ANALYTICAL BIOCHEMISTRY, 1982, 126 (01) :131-138

[9] Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, C-myc, Bcl-XL, NF-κB, and p53 [J].

Han, SS ;

Chung, ST ;

Robertson, DA ;

Ranjan, D ;

Bondada, S .

CLINICAL IMMUNOLOGY, 1999, 93 (02) :152-161

[10] Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway [J].

Hanif, R ;

Qiao, L ;

Shiff, SJ ;

Rigas, B .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1997, 130 (06) :576-584

← 1 2 3 →