Neolignan inhibitors of antigen-induced degranulation in RBL-2H3 cells from the needles of Pinus thunbergii

被引：14

作者：

Hong, Seong Su ^{[1
]}

Jeong, Wonsik ^{[1
,2
]}

Kim, Jin Kyu ^{[1
]}

Kwon, Jin Gwan ^{[1
]}

Lee, Jae Yeon ^{[1
]}

Ahn, Eun-Kyung ^{[1
]}

Oh, Junho ^{[3
]}

Seo, Dong-Wan ^{[2
]}

Oh, Joa Sub ^{[1
,2
]}

机构：

[1] Inst Nat Prod Res, Gyeonggi Inst Sci & Technol Promot, Suwon 443766, South Korea

[2] Dankook Univ, Coll Pharm, Cheonan 330714, South Korea

[3] Duke Univ, Dept Biol, Durham, NC 27708 USA

来源：

FITOTERAPIA | 2014年 / 99卷

关键词：

Pinus thunbergii; Neolignan glycoside; Pinusthunbergiside A; beta-hexosaminidase; LIGNAN GLYCOSIDES; ANTIOXIDANT; DENSIFLORA; ACID; FLAVONOIDS; EXTRACT; ASTHMA;

D O I：

10.1016/j.fitote.2014.10.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The ethanolic extract of the needles of Pinus thunbergii was found to suppress antigen mediated degranulation of rat basophilic leukemia (RBL-2H3) cells. A new neolignan glycoside, named pinusthunbergiside A (1), as well as six known neolignan glycosides (2-7) were isolated from the ethanolic extract using bioassay-guided fractionation. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and circular dichroism (CD) data. Compounds 2-7 were found for the first time in this plant. The inhibitory effects of isolated constituents on the release of (beta-hexosaminidase from RBL-2H3 cells were examined, and compounds 2, 3, 5, and 6 were found to show the inhibitory activity with IC50 values ranging between 52.3 and 75.3 mu M. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：347 / 351

页数：5

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