Treat to Target A Valid Concept for Management of Polymyalgia Rheumatica and Giant Cell Arteritis?

被引：10

作者：

Camellino, Dario ^{[1
,2
]}

Dejaco, Christian ^{[3
,4
]}

Buttgereit, Frank ^{[5
]}

Matteson, Eric L. ^{[6
,7
,8
]}

机构：

[1] La Colletta Hosp, Div Rheumatol, Azienda Sanit Locale 3,Via Giappone 3, I-16011 Genoa, Italy

[2] Univ Genoa, Dept Internal Med, Autoimmunol Lab, Viale Benedetto XV 6, I-16132 Genoa, Italy

[3] Hosp Bruneck, Rheumatol Serv, South Tyrolean Hlth Trust, Spitalstr 11, I-39031 Brunico, Italy

[4] Med Univ Graz, Dept Rheumatol, Auenbruggerpl 15-19, A-8036 Graz, Austria

[5] Charite Univ Med Berlin CCM, Dept Rheumatol & Clin Immunol, Charitepl 1, D-10117 Berlin, Germany

[6] Mayo Clin, Div Rheumatol, Coll Med, Rochester, MN 55905 USA

[7] Mayo Clin, Dept Hlth Sci Res, Coll Med, 200 1st St SW, Rochester, MN 55905 USA

[8] Christchurch Hosp, Dept Rheumatol Immunol & Allergy, PB 4710, Christchurch 8140, New Zealand

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2019年 / 45卷 / 04期

关键词：

Giant cell arteritis; Polymyalgia rheumatica; Treat to target; Glucocorticoids; Biologics; Patient-reported outcomes; LARGE-VESSEL VASCULITIS; PATIENT-REPORTED OUTCOMES; C-REACTIVE PROTEIN; DISEASE-ACTIVITY; DOUBLE-BLIND; ACTIVITY SCORE; TO-TARGET; ISCHEMIC COMPLICATIONS; EMISSION-TOMOGRAPHY; AORTIC-ANEURYSM;

D O I：

10.1016/j.rdc.2019.07.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common inflammatory diseases of the elderly. They have variable clinical courses and are usually treated with glucocorticoids (GCs). Relapses are frequent in both conditions. Physicians should balance the tradeoff of treatment-related adverse events and risk of relapse. The ultimate goal of treatment is control of the disease while maintaining patient well-being. A treat to target approach may achieve the aim of controlling inflammation and preserving patient's functioning and quality of life, and would require pursuit and evaluation of clinical, laboratory, imaging, and structural targets to tackle the different manifestations of GCA and PMR.

引用

页码：549 / +

页数：20

共 97 条

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