Ionic liquid mediated synthesis of labelled peptide nucleic acid monomer

被引：1

作者：

Athira, C. K. ^{[1
]}

Manikandan, Priyadharshini ^{[1
]}

Kandasamy, Elango ^{[1
]}

Ramani, Prasanna ^{[1
]}

机构：

[1] Amrita Vishwa Vidyapeetham, Amrita Sch Engn, Dept Sci, Dhanvanthri Lab, Coimbatore, Tamil Nadu, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2019年 / 18卷

关键词：

amino acids; peptide nucleic acids; alkylation; ionic liquids; phthalimides; PNA; RNA;

D O I：

10.1016/j.matpr.2019.05.271

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We have designed and synthesized phthalimido labelled peptide nucleic acid (PNA) monomer through N-alkylation of a-amino acid ester with N-bromo ethylphthalimide which was facilitated by using ionic liquids. The alkylated product was condensed with nucleobase such as thymine-1-acetic acid to get the target compound. The labelled-PNA monomer is a new molecule which bears a marker and can be easily prepared in two steps. (C) 2019 Published by Elsevier Ltd.

引用

页码：1735 / 1739

页数：5

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