Genotoxic activity of important nitrobenzenes and nitroanilines in the Ames test and their structure-activity relationship

被引:30
作者
Assmann, N
Emmrich, M [1 ]
Kampf, G
Kaiser, M
机构
[1] Free Univ Berlin, Inst Hyg Environm & Occupat Med, D-12203 Berlin, Germany
[2] Def Inst Mat Explos Fuels & Lubricants, D-53913 Swisttal, Germany
关键词
mutagenicity; Salmonella typhimurium; Ames assay; nitrobenzenes; nitroanilines; explosives;
D O I
10.1016/S1383-5718(97)00158-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The most important commercially available nitro-and aminobenzenes and the explosive trinitrobenzene were tested for mutagenicity in the Salmonella typhymurium TA 98 and TA 100 both in the absence and presence of S 9. Ten of the 14 compounds tested (71%) were mutagenic. All the substances showed positive results in TA 98 and 4 substances were also mutagenic in TA 100. The three diaminobenzenes and 4-nitroaniline were mutagenic only with metabolic activation. All other compounds did not require the addition of S 9. Only nitrobenzene, 1,2-dinitrobenzene, aniline and 2-nitroaniline were negative in both strains. In summary, all substances that are derived from nitrobenzene or aniline by addition of a nitro group in the meta- or para-position were mutagenic, whereas nitrobenzene and aniline themselves and their ortho-derivates were nonmutagenic. The possible relationships between the position of the substituents and the mutagenicity are discussed. (C) 1997 Elsevier Science B.V.
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页码:139 / 144
页数:6
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