The role of stereotactic radiotherapy in addition to immunotherapy in the management of melanoma brain metastases: results of a systematic review

被引：19
作者：
Lancellotta, Valentina [1 ]
Del Regno, Laura [2 ]
Di Stefani, Alessandro [2 ,3 ]
Fionda, Bruno [1 ]
Marazzi, Fabio [1 ]
Rossi, Ernesto [4 ]
Balducci, Mario [1 ]
Pampena, Riccardo [5 ,6 ]
Morganti, Alessio Giuseppe [6 ,7 ]
Mangoni, Monica [8 ]
Lebbe, Celeste [9 ]
Garbe, Claus [10 ,11 ,12 ,13 ,14 ]
Longo, Caterina [5 ,6 ]
Schinzari, Giovanni [4 ]
Tagliaferri, Luca [1 ]
Peris, Ketty [2 ,3 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Diagnost Immagini Radioterapia Oncol, UOC Radioterapia Oncol, Rome, Italy
[2] Catholic Univ, Inst Dermatol, Rome, Italy
[3] Fdn Policlin Univ A Gemelli, IRCCS, Rome, Italy
[4] Fdn Policlin Univ Agostino Gemelli IRCCS, Med Oncol, Rome, Italy
[5] Univ Modena & Reggio Emilia, Ctr Oncol & Alta Tecnol Diagnost, Dept Dermatol, Azienda Unita Sanitaria Locale Ist Ricovero & Cur, Modena, Italy
[6] Azienda Osped Univ Bologna, Radiotherapy Ctr, Bologna, Italy
[7] Univ Bologna, DIMES, Alma Mater Studiorum, Bologna, Italy
[8] Univ Florence, Azienda Osped Univ Careggi, Radiat Oncol Unit, Florence, Italy
[9] Univ Paris, St Louis Hosp, AP HP Dermatol, INSERM,U976, Paris, France
[10] Inst Gustave Roussy, Villejuif, France
[11] Paris Sud Paris Saclay Univ, Villejuif, France
[12] Aix Marseille Univ, Marseille, France
[13] Univ Paris, Hop St Louis, Assistance Publ Hop Paris Dermatol, Paris, France
[14] Univ Paris, Hop St Louis, Clin Invest Ctr, Unite 976, Paris, France
来源：
RADIOLOGIA MEDICA | 2022年 / 127卷 / 07期
关键词：
Stereotactic radiotherapy; Immunotherapy; Brain metastases; Overall survival; Toxicity; OPEN-LABEL; IPILIMUMAB; RADIOSURGERY; SURVIVAL; THERAPY;
D O I：
10.1007/s11547-022-01503-7
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Aim of this study was to systematically review the literature to assess efficacy and safety of stereotactic radiotherapy (SRT) in combination with immunotherapy for the treatment of melanoma brain metastases (MBM). The literature was searched using PubMed, Scopus, and Embase. Studies comparing SRT plus immunotherapy versus SRT or immunotherapy alone were deemed eligible for inclusion. Two studies showed improved overall survival after SRT plus immunotherapy in melanoma cancer patients with brain metastases. Three studies reported data on LC and DFS showing as SRT plus immunotherapy did not improve local control and DFS rates. G3-G4 toxicity was reported in only one study (20% in the SRT plus immunotherapy group versus 23% in the immunotherapy group). Despite SRT plus concurrent immunotherapy seems associated with possible survival advantage and low >= G3 late toxicity rates, the quality of evidence is very low. Therefore, in patients with brain metastases from melanoma, SRT plus immunotherapy should be evaluated on an individual basis after discussion by a multidisciplinary team.
引用
收藏
页码：773 / 783
页数：11
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