Bismuth subnitrate catalyzed efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones: An improved protocol for the Biginelli reaction

被引：39

作者：

Reddy, YT ^{[1
]}

Rajitha, B ^{[1
]}

Reddy, PN ^{[1
]}

Kumar, BS ^{[1
]}

Rao, VP ^{[1
]}

机构：

[1] Natl Inst Technol, Dept Chem, Warangal, India

来源：

SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 20期

关键词：

Biginelli reaction; bismuth subnitrate; dihydropyrimidinones; one-pot condensation;

D O I：

10.1081/SCC-200032533

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, beta-ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88-96%) and short reaction times (1.5-4h) than do classical Biginelli reaction conditions.

引用

页码：3821 / 3825

页数：5

共 19 条

[1]

ATWAL KS, 1987, HETEROCYCLES, V26, P1189

[2] SUBSTITUTED 1,4-DIHYDROPYRIMIDINES .3. SYNTHESIS OF SELECTIVELY FUNCTIONALIZED 2-HETERO-1,4-DIHYDROPYRIMIDINES [J].