Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions

被引：29

作者：

Bitto, Alessandra ^{[1
]}

Squadrito, Francesco ^{[1
]}

Irrera, Natasha ^{[1
]}

Pizzino, Gabriele ^{[1
]}

Pallio, Giovanni ^{[1
]}

Mecchio, Anna ^{[1
]}

Galfo, Federica ^{[1
]}

Altavilla, Domenica ^{[2
]}

机构：

[1] Univ Messina, AOU Policlin G Martino, Pharmacol Sect, Dept Clin & Expt Med, I-98125 Messina, Italy

[2] Univ Messina, Dept Paediat Gynaecol Microbiol & Biomed Sci, I-98125 Messina, Italy

来源：

MEDIATORS OF INFLAMMATION | 2014年 / 2014卷

关键词：

NF-KAPPA-B; ATTENUATES OXIDANT STRESS; SCUTELLARIA-BAICALENSIS; DUAL INHIBITOR; ACACIA-CATECHU; CYCLOOXYGENASE-2; INHIBITORS; ANTIINFLAMMATORY AGENT; PLANT FLAVONOIDS; REL PROTEINS; EXTRACT;

D O I：

10.1155/2014/790851

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Flavonoids, from Scutellaria baicalensis (Chinese skullcap) and Acacia catechu (black catechu), have been shown to exert a variety of therapeutic effects, including anti-inflammatory, antiviral, antibacterial, and anticancer activities. Flavocoxid is a mixed extract containing baicalin and catechin and it acts as a dual balanced inhibitor of cyclooxygenase-1 (COX-1) and COX-2 peroxidase enzyme activities with a significant inhibition of 5-lipoxygenase (5-LOX)enzyme activity in vitro. Flavocoxid downregulates gene or protein expression of several inflammatory markers and exerts also strong antioxidant activity in several experimental models. Controlled clinical trials and a postmarketing study have clearly shown that flavocoxid is as effective as naproxen in managing the signs and symptoms of osteoarthritis of the knee and it has better upper gastrointestinal, renal, and respiratory safety profile than naproxen. Flavocoxid may therefore provide a potential therapeutic approach to the treatment of chronic inflammatory conditions.

引用

页数：8

共 45 条

[1] RETRACTED: Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia (Retracted Article) [J].