Modulation of P-glycoprotein ATPase Activity by Some Phytoconstituents

被引：81

作者：

Najar, I. A. ^{[1
]}

Sachin, B. S. ^{[1
]}

Sharma, S. C. ^{[1
]}

Satti, N. K. ^{[2
]}

Suri, K. A. ^{[2
]}

Johri, R. K. ^{[1
]}

机构：

[1] CSIR, Indian Inst Integrat Med, Div Pharmacol, Jammu 180001, India

[2] CSIR, Indian Inst Integrat Med, Div Nat Prod Chem, Jammu 180001, India

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 03期

关键词：

P-glycoprotein; ATPase activity; phytoconstituents; DRUG-INTERACTIONS; TRANSPORTER; INHIBITION;

D O I：

10.1002/ptr.2951

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present investigation 16 phytoconstituents, which are active moieties round in several medicinal herbs, have been evaluated for their P-glycoprotein (P-gp) stimulation/inhibition profiles using a P-gp-dependent ATPase assay in rat jejunal membrane (in vitro). Acteoside, agnuside, catechin, chlorogenic acid, picroside -II and santonin showed an inhibitory effect. Negundoside., picroside -I and oleanolic acid caused a stimulatory effect. Andrographolide, apocyanin, berberine, glycyrrhizin, magniferin and piperine produced a biphasic response (stimulation at low concentration and inhibition at high concentration). The results suggested that a possible interaction of these phytoconstituents at the level or P-gp, could be an important parameter in determining their role in several key pharmacodynamic events. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：454 / 458

页数：5

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