Amyloid Cardiomyopathy Disease on the Rise

被引：18

作者：

Liao, Ronglih

Ward, Jennifer E.

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA USA

来源：

CIRCULATION RESEARCH | 2017年 / 120卷 / 12期

关键词：

aging; amyloid; gadolinium; heart failure; mutation; SENILE SYSTEMIC AMYLOIDOSIS; ALZHEIMERS-DISEASE; TRANSTHYRETIN; MODEL; MICE;

D O I：

10.1161/CIRCRESAHA.117.310643

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloidoses represent a group of human degenerative diseases characterized by the deposition of aggregates of abnormally folded proteins in single or multi-organs. Whereas neurological amyloidoses, such as Alzheimer and Parkinson disease, have received the greatest recognition, there also exists many systemic amyloidoses that affect many target organs, including the heart.

引用

页码：1865 / 1867

页数：3

共 15 条

[11]

SOLOMON A, 1992, AM J PATHOL, V140, P629

[12] Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau:: A population-based autopsy study [J].