The apical seal of roots obturated with either of two kinds of dentin bonding agent, gutta-percha and epoxy-resin-based root canal sealer, was compared by a die leakage test with that of an epoxy resin root canal sealer and gutta-percha without a bonding agent, Thirty-two roots were prepared chemomechanically and divided into three experimental groups, Group 1 was filled with gutta-percha, epoxy-resin sealer, and All-Bond 2 Adhesive, Group 2 was filled with gutta-percha, epoxy-resin sealer, and Scotchbond Multi-Purpose Plus adhesive, Group 3 was filled with gutta-percha and epoxy resin sealer, The teeth were immersed in 2% methylene blue solution, Groups 1 and 2 leaked significantly less than group 3, The materials most frequently observed at the apex were in group 1 dental adhesive and in group 2 gutta-percha, The interface between dentin and the adhesive materials in groups 1 and 2 was examined by scanning electron microscope and showed a hybrid-like layer.