Ultralow-intensity near-infrared light induces drug delivery by upconverting nanoparticles

被引：161

作者：

He, Shuqing ^{[1
]}

Krippes, Kristina ^{[1
]}

Ritz, Sandra ^{[1
]}

Chen, Zhijun ^{[1
]}

Best, Andreas ^{[1
]}

Butt, Hans-Juergen ^{[1
]}

Mailaender, Volker ^{[1
,2
]}

Wu, Si ^{[1
]}

机构：

[1] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med, Med Clin 3, D-55131 Mainz, Germany

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 02期

关键词：

UP-CONVERSION LUMINESCENCE; MESOPOROUS SILICA; NIR-LIGHT; RELEASE; NANOCARRIERS; COMPLEXES; PHOTON;

D O I：

10.1039/c4cc07489k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mesoporous silica coated upconverting nanoparticles are loaded with the anticancer drug doxorubicin and grafted with ruthenium complexes as photoactive molecular valves. Drug release was triggered by 974 nm light with 0.35 W cm(-2). Such low light intensity minimized overheating problems and prevented photodamage to biological samples.

引用

收藏

页码：431 / 434

页数：4

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