Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights

被引：53

作者：

Kumar, Sandeep ^{[1
]}

Singh, Sunil Kumar ^{[1
]}

Rana, Basabi ^{[1
,2
,3
]}

Rana, Ajay ^{[1
,2
,3
]}

机构：

[1] Univ Illinois, Div Surg Oncol, Dept Surg, Chicago, IL 60612 USA

[2] Univ Illinois, Univ Illinois Hosp & Hlth Sci Syst Canc Ctr, Chicago, IL 60612 USA

[3] Jesse Brown VA Med Ctr, Chicago, IL 60612 USA

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 04期

关键词：

INTRATUMORAL IMMUNOTHERAPY; LYMPHOCYTE THERAPY; PHOSPHORYLATED ERK; PD-1; BLOCKADE; LUNG-CANCER; CHECKPOINT; MELANOMA; IMMUNITY; ANTIGEN; AGONIST;

D O I：

10.1016/j.drudis.2021.01.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Host immunity has an essential role in the clinical management of cancers. Therefore, it is advantageous to choose therapies that can promote tumor cell death and concurrently boost host immunity. The dynamic tumor microenvironment (TME) determines whether an antineoplastic drug will elicit favorable or disparaging immune responses from tumor-infiltrating lymphocytes (TILs). CD8+ T cells are one of the primary tumor-infiltrating immune cells that deliver antitumor responses. Here, we review the influence of various factors in the TME on CD8+ T cell exhaustion and survival, and possible strategies for restoring CD8+ T cell effector function through immunotherapy.

引用

页码：951 / 967

页数：17

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