Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion: molecular insights

被引：39
作者：
Kumar, Sandeep [1 ]
Singh, Sunil Kumar [1 ]
Rana, Basabi [1 ,2 ,3 ]
Rana, Ajay [1 ,2 ,3 ]
机构：
[1] Univ Illinois, Div Surg Oncol, Dept Surg, Chicago, IL 60612 USA
[2] Univ Illinois, Univ Illinois Hosp & Hlth Sci Syst Canc Ctr, Chicago, IL 60612 USA
[3] Jesse Brown VA Med Ctr, Chicago, IL 60612 USA
来源：
DRUG DISCOVERY TODAY | 2021年 / 26卷 / 04期
关键词：
INTRATUMORAL IMMUNOTHERAPY; LYMPHOCYTE THERAPY; PHOSPHORYLATED ERK; PD-1; BLOCKADE; LUNG-CANCER; CHECKPOINT; MELANOMA; IMMUNITY; ANTIGEN; AGONIST;
D O I：
10.1016/j.drudis.2021.01.002
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Host immunity has an essential role in the clinical management of cancers. Therefore, it is advantageous to choose therapies that can promote tumor cell death and concurrently boost host immunity. The dynamic tumor microenvironment (TME) determines whether an antineoplastic drug will elicit favorable or disparaging immune responses from tumor-infiltrating lymphocytes (TILs). CD8+ T cells are one of the primary tumor-infiltrating immune cells that deliver antitumor responses. Here, we review the influence of various factors in the TME on CD8+ T cell exhaustion and survival, and possible strategies for restoring CD8+ T cell effector function through immunotherapy.
引用
收藏
页码：951 / 967
页数：17
相关论文
共 208 条
  • [1] Toll-like receptor agonists in cancer therapy
    Adams, Sylvia
    [J]. IMMUNOTHERAPY, 2009, 1 (06) : 949 - 964
  • [2] Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    Ahmadzadeh, Mojgan
    Johnson, Laura A.
    Heemskerk, Bianca
    Wunderlich, John R.
    Dudley, Mark E.
    White, Donald E.
    Rosenberg, Steven A.
    [J]. BLOOD, 2009, 114 (08) : 1537 - 1544
  • [3] Tumor infiltrating lymphocyte therapy for ovarian cancer and renal cell carcinoma
    Andersen, Rikke
    Donia, Marco
    Westergaard, Marie Christine Wulff
    Pedersen, Magnus
    Hansen, Morten
    Svane, Inge Marie
    [J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2015, 11 (12) : 2790 - 2795
  • [4] Carboplatin chemoresistance is associated with CD11b+/Ly6C+ myeloid release and upregulation of TIGIT and LAG3/CD160 exhausted T cells
    Anestakis, Doxakis
    Petanidis, Savvas
    Domvri, Kalliopi
    Tsavlis, Drosos
    Zarogoulidis, Paul
    Katopodi, Theodora
    [J]. MOLECULAR IMMUNOLOGY, 2020, 118 : 99 - 109
  • [5] Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy
    Baumann, Daniel
    Haegele, Tanja
    Mochayedi, Julian
    Drebant, Jennifer
    Vent, Caroline
    Blobner, Sven
    Noll, Julia Han
    Nickel, Irena
    Schumacher, Corinna
    Boos, Sophie Luise
    Daniel, Aline Sophie
    Wendler, Susann
    Volkmar, Michael
    Strobel, Oliver
    Offringa, Rienk
    [J]. NATURE COMMUNICATIONS, 2020, 11 (01)
  • [6] Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8+ T Cell Exhaustion
    Bengsch, Bertram
    Johnson, Andy L.
    Kurachi, Makoto
    Odorizzi, Pamela M.
    Pauken, Kristen E.
    Attanasio, John
    Stelekati, Erietta
    McLane, Laura M.
    Paley, Michael A.
    Delgoffe, Greg M.
    Wherry, E. John
    [J]. IMMUNITY, 2016, 45 (02) : 358 - 373
  • [7] Blocking Tumor Necrosis Factor a Enhances CD8 T-cell-Dependent Immunity in Experimental Melanoma
    Bertrand, Florie
    Rochotte, Julia
    Colacios, Celine
    Montfort, Anne
    Tilkin-Mariame, Anne-Francoise
    Touriol, Christian
    Rochaix, Philippe
    Lajoie-Mazenc, Isabelle
    Andrieu-Abadie, Nathalie
    Levade, Thierry
    Benoist, Herve
    Segui, Bruno
    [J]. CANCER RESEARCH, 2015, 75 (13) : 2619 - 2628
  • [8] Interferon-γ derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity
    Bhat, Purnima
    Leggatt, Graham
    Waterhouse, Nigel
    Frazer, Ian H.
    [J]. CELL DEATH & DISEASE, 2017, 8 : e2836 - e2836
  • [9] Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis
    Brackett, Craig M.
    Kojouharov, Bojidar
    Veith, Jean
    Greene, Kellee F.
    Burdelya, Lyudmila G.
    Gollnick, Sandra O.
    Abrams, Scott I.
    Gudkov, Andrei V.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (07) : E874 - E883
  • [10] Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function
    Buchan, Sarah L.
    Dou, Lang
    Remer, Marcus
    Booth, Steven G.
    Dunn, Stuart N.
    Lai, Chester
    Semmrich, Monika
    Teige, Ingrid
    Martensson, Linda
    Penfold, Christine A.
    Chan, H. T. Claude
    Willoughby, Jane E.
    Mockridge, C. Ian
    Dahal, Lekh N.
    Cleary, Kirstie L. S.
    James, Sonya
    Rogel, Anne
    Kannisto, Paivi
    Jernetz, Mats
    Williams, Emily L.
    Healy, Eugene
    Verbeek, J. Sjef
    Johnson, Peter W. M.
    Frendeus, Bjorn
    Cragg, Mark S.
    Glennie, Martin J.
    Gray, Juliet C.
    Al-Shamkhani, Aymen
    Beers, Stephen A.
    [J]. IMMUNITY, 2018, 49 (05) : 958 - +
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