A mitotic role for the DNA damage-responsive CHK2 kinase

被引：12

作者：

Sato, Ko ^{[1
,2
]}

Ohta, Tomohiko ^{[3
]}

Venkitaraman, Ashok R. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Oncol, Cambridge CB2 0XZ, England

[2] Univ Cambridge, MRC, Canc Cell Unit, Hutchison MRC Res Ctr, Cambridge CB2 0XZ, England

[3] St Marianna Univ, Grad Sch Med, Dept Translat Oncol, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 05期

基金：

英国医学研究理事会;

关键词：

REGULATES MCAK; AURORA-B; PHOSPHORYLATION; REPLICATION; CANCER;

D O I：

10.1038/ncb0510-424

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Instability in the structure and number of chromosomes is a trait common to cells from most epithelial cancers. A role in chromosome segregation for a pathway previously implicated in the DNA damage response reveals new connections between the tumour suppressive processes that maintain chromosome integrity.

引用

页码：424 / 425

页数：2

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