Variation of polymorphic region C of the protein A gene during persistent airway infection of cystic fibrosis patients reflects two independent mechanisms of genetic change in Staphylococcus aureus

被引：83
作者：
Kahl, BC
Mellmann, A
Deiwick, S
Peters, G
Harmsen, D
机构：
[1] Univ Munster, inst Med Microbiol, D-48149 Munster, Germany
[2] Univ Munster, Inst Hyg, D-48149 Munster, Germany
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 01期
关键词：
D O I：
10.1128/JCM.43.1.502-505.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Variation of the polymorphic region of the protein A gene (spa) was observed during long-term persistence of Staphylococcus aureus in the airways of 10 cystic fibrosis patients and occurred at a rate of one genetic change every 70 months. Independent mutational events were observed eight times in 142 isolates: four deletions, two duplications of repeats, and two point mutations.
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页码：502 / 505
页数：4
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