Leptin fluctuates in intestinal ischemia-reperfusion injury as inflammatory cytokine

被引：22

作者：

Lin, J ^{[1
]}

Yan, GT ^{[1
]}

Wang, LH ^{[1
]}

Hao, XH ^{[1
]}

Zhang, K ^{[1
]}

Xue, H ^{[1
]}

机构：

[1] Gen Hosp PLA, Basic Med Inst, Biochem Res Lab, Beijing 100853, Peoples R China

来源：

PEPTIDES | 2004年 / 25卷 / 12期

基金：

中国国家自然科学基金;

关键词：

leptin; ischemia-reperfusion; intestinal; inflammation; acute; adipose; cytokine; radioimmunoassay;

D O I：

10.1016/j.peptides.2004.08.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As leptin is an active mediator mainly secreted by adipose tissue and is closely related with energy metabolism. we evaluate both the changes of leptin levels in serum and adipose tissue with a concise radioinummoassay and the changes of leptin mRNA expression in adipose tissue with RT-PCR, during the severe metabolic impediment in rat intestinal ischemia-reperfusion (I/R) injury. Results;;how that no( only leptin levels in serum and adipose tissue but also its mRNA expression in adipose tissue undergo a fluctuation according to different injury, times. Therefore, we conclude that leptin has a time-dependent response to acute inflammatory stimuli and acts as an anti-inflammatory cytokine. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：2187 / 2193

页数：7

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