Skin regeneration using duck's feet derived collagen and poly(vinyl alcohol) scaffold

被引：9

作者：

Song, Jeong Eun ^{[1
,2
]}

Tripathy, Nirmalya ^{[1
,2
]}

Shin, Jae Hun ^{[1
,2
]}

Lee, Dae Hoon ^{[1
,2
]}

Park, Chan Hum ^{[3
]}

Khang, Gilson ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Polymer Fusion Res Ctr, Dept BIN Fus Tech, 567 Baekje Daero, Jeonju 54898, South Korea

[2] Chonbuk Natl Univ, Dept Polymer Nano Sci Tech, 567 Baekje Daero, Jeonju 54898, South Korea

[3] Hallym Univ, Chuncheon Sacred Heart Hosp, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, 77 Sakju Ro, Chunchon 24253, Gangwon, South Korea

来源：

MACROMOLECULAR RESEARCH | 2016年 / 24卷 / 04期

关键词：

duck's feet derived collagen; poly(vinyl alcohol); scaffold; freezing thawing; skin regeneration; IN-VITRO; FABRICATION; PROLIFERATION; FIBROBLASTS; SPONGE; CELLS; VIVO;

D O I：

10.1007/s13233-016-4051-3

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this study, we have designed scaffold by mixing collagen extracted from the duck's flippers with poly(vinyl alcohol) (DC/PVA) via freeze-thawing and the as-prepared scaffold were evaluated for skin regeneration. The physical and chemical properties of the scaffolds were characterized using FTIR, SEM, compressive strength, degree of swelling, etc. The in vitro behavior (cell proliferation) was examined after cultured with fibroblasts through the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay. The in vivo results demonstrated that the scaffolds implanted in rat induced full-thickness defect, confirmed by histological staining. Encompassing all results, the DC/PVA scaffolds can be anticipated as efficient platforms for skin regeneration facilitating required cell adhesion, growth and proliferation.

引用

页码：359 / 365

页数：7

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