Enantioselective reduction of nitroalkene mixtures by in situ equilibration

被引：25

作者：

Czekelius, Constantin ^{[1
]}

Carreira, Erick M. ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2007年 / 11卷 / 03期

关键词：

D O I：

10.1021/op700029m

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We document an easy protocol for the enantioselective conjugate reduction of isomeric mixtures of nitroalkenes. Employing a catalyst from (CuOBu)-Bu-t and JOSIPHOS, conjugated and nonconjugated isomers are interconverted by the action of quaternary ammonium bases, and both reduced enantioselectively to the corresponding nitroalkanes.

引用

页码：633 / 636

页数：4

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