Genus Lonicera: New drug discovery from traditional usage to modern chemical and pharmacological research

被引：36

作者：

Ge, Lanlan ^{[1
,2
,3
,4
]}

Xie, Qiujie ^{[1
,2
,3
]}

Jiang, Yuanyuan ^{[1
,2
,3
]}

Xiao, Lingyun ^{[1
,2
,3
]}

Wan, Haoqiang ^{[1
,2
,3
,4
]}

Zhou, Boping ^{[1
,2
,3
]}

Wu, Shipin ^{[1
,2
,3
]}

Tian, Jun ^{[5
]}

Zeng, Xiaobin ^{[1
,2
,3
,4
,6
]}

机构：

[1] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Ctr Lab Longhua Branch, Shenzhen 518020, Guangdong, Peoples R China

[2] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Infect Dis, Shenzhen 518020, Guangdong, Peoples R China

[3] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China

[4] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Pathol,Longhua Branch, Shenzhen 518020, Guangdong, Peoples R China

[5] Jiangsu Normal Univ, Coll Life Sci, Xuzhou 221116, Jiangsu, Peoples R China

[6] Shenzhen Univ, Med Sch, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen 518037, Guangdong, Peoples R China

来源：

PHYTOMEDICINE | 2022年 / 96卷

基金：

中国国家自然科学基金;

关键词：

Genus Lonicera; Traditional usage; Chemical constituents; Pharmacological activities; NF-KAPPA-B; REDUCES CHOLESTEROL ACCUMULATION; CAFFEOYLQUINIC ACID-DERIVATIVES; ESTER IRIDOID GLUCOSIDE; JAPONICA FLOWER BUDS; PHOSPHATASE 1B PTP1B; TRITERPENOID SAPONINS; ESSENTIAL OIL; VOLATILE CONSTITUENTS; IN-VITRO;

D O I：

10.1016/j.phymed.2021.153889

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Background: Lonicera Linn. belonging to the family Caprifoliaceae, the largest genus in the plant family, includes about more than 200 species, which are mainly distributed in northern Africa, North America, Europe and Asia. Some species of this genus have been usually used in traditional Chinese medicine as well as functional foods, cosmetics and other applications, such as L. japonica Thunb. Bioactive components and pharmacological activities of the genus Lonicera plants have received an increasing interest from the scientific community. Thus, a comprehensive and systematic review on their traditional usage in China, chemical components, and their pharmacological properties of their whole plants, bioactive extracts, and bioactive isolates including partial structure-activity relationships from the genus is indispensable. Methods: Information on genus Lonicera of this systematic electronic literature search was gathered via the published articles, patents, clinical trials website (https://clinicaltrials.gov/) and several online bibliographic databases (PubMed, Sci Finder, Research Gate, Science Direct, CNKI, Web of Science and Google Scholar). The following keywords were used for the online search: Lonicera, phytochemical composition, Lonicerae japonica, Lonicera review articles, bioactivities of Lonicera, anti-inflammatory, antiviral, antimicrobial, anticancer, hepatoprotective, antioxidant, neuroprotective, anti-diabetic, and clinical trials. This review paper consists of a total of 225 papers covering the Lonicera genus from 1800 to 2021, including research articles, reviews, patents, and book chapters. Results: In this review (1800s-2021), about 420 components from the genus of Lonicera Linn. including 87 flavonoids, 222 terpenoids, 51 organic acids, and other compounds, together with their pharmacological activities including anti-inflammatory, antiviral, antimicrobial, anticancer, hepatoprotective, antioxidant, neuro-protective, antidiabetic, anti-allergic, immunomodulatory effects, and toxicity were summarized. Conclusion: The relationship is discussed among their traditional usage, their pharmacological properties, and their chemical components, which indicate the genus Lonicera have a large prospect in terms of new drug exploitation, especially in COVID-19 treatment.

引用

页数：38

共 223 条

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