Mutant prevention concentration as a measure of antibiotic potency:: Studies with clinical isolates of Mycobacterium tuberculosis

被引：105
作者：
Dong, YZ [1 ]
Zhao, XL [1 ]
Kreiswirth, BN [1 ]
Drlica, K [1 ]
机构：
[1] Publ Hlth Res Inst, New York, NY 10016 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 09期
关键词：
D O I：
10.1128/AAC.44.9.2581-2584.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in having MPCs below the maximum concentration attained in serum by use of commonly recommended doses.
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页码：2581 / 2584
页数：4
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