Copper-catalysed asymmetric 1,4-addition of organometallic reagents to 2-cyclohexenone using novel phosphine-phosphite ligands

被引：45
作者：
Diéguez, M
Deerenberg, S
Pàmies, O
Claver, C
van Leeuwen, PWNM
Kamer, P
机构：
[1] Univ Amsterdam, Inst Mol Chem, NL-1018 WV Amsterdam, Netherlands
[2] Univ Rovira & Virgili, Dept Quim Fis & Inorgan, Tarragona 43005, Spain
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 15期
关键词：
D O I：
10.1016/S0957-4166(00)00262-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of novel non-symmetrical phosphine-phosphite ligands 1-10 have been tested in the copper catalysed asymmetric addition of diethylzinc and triethylaluminium to 2-cyclohexenone. In all cases, excellent conversion and regioselectivities for the 1,4-product were found. Good enantiomeric excesses (up to 62%) were obtained when triethylaluminium was used as the alkylating reagent. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：3161 / 3166
页数：6
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