Polymer-peptide chimeras for the multivalent display of immunogenic peptides

被引：28

作者：

Kakwere, Hamilton ^{[1
]}

Chun, Candy K. Y.

Jolliffe, Katrina A.

Payne, Richard J. ^{[1
]}

Perrier, Sebastien ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 13期

基金：

澳大利亚研究理事会;

关键词：

FRAGMENTATION CHAIN TRANSFER; TUMOR-SELECTIVE VACCINES; SYNTHETIC GLYCOPEPTIDES; CLICK CHEMISTRY; RADICAL POLYMERIZATION; BLOCK-COPOLYMERS; TERMINAL ALKYNES; RAFT; MUC1; DESIGN;

D O I：

10.1039/b924112d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chimeras of poly(n-isopropyl acrylamide) and immunogenic peptides from the cancer-associated glycoprotein MUC1 were synthesised using a combination of solid-phase peptide synthesis, RAFT polymerisation and copper-catalysed alkyne-azide cyclo-addition reactions.

引用

页码：2188 / 2190

页数：3

共 34 条

[1] Developmental toxicity assessment of thermoresponsive poly(N-isopropylacrylamide-Co-acrylamide) oligomers in CD-1 mice [J].

Ankareddi, Induvadana ;

Bailey, Melissa M. ;

Brazel, Christopher S. ;

Rasco, Jane E. ;

Hood, Ronald D. .

BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 2008, 83 (02) :112-116

[2]

[Anonymous], 2003, HDB RADICAL POLYMERI

[3] 'Click' chemistry in polymer and material science: An update [J].

Binder, Wolfgang H. ;

Sachsenhofer, Robert .

MACROMOLECULAR RAPID COMMUNICATIONS, 2008, 29 (12-13) :952-981

[4] Glycopeptides as versatile tools for glycobiology [J].

Buskas, Therese ;

Ingale, Sampat ;

Boons, Geert-Jan .

GLYCOBIOLOGY, 2006, 16 (08) :113R-136R

[5] Immunotherapy for cancer: synthetic carbohydrate-based vaccines [J].

Buskas, Therese ;

Thompson, Pamela ;

Boons, Geert-Jan .

CHEMICAL COMMUNICATIONS, 2009, (36) :5335-5349

[6] Synthesis of shell cross-linked micelles at high solids in aqueous media [J].

Bütün, V ;

Wang, XS ;

Báñez, MVD ;

Robinson, KL ;

Billingham, NC ;

Armes, SP ;

Tuzar, Z .

MACROMOLECULES, 2000, 33 (01) :1-3

[7] Living free-radical polymerization by reversible addition-fragmentation chain transfer: The RAFT process [J].

Chiefari, J ;

Chong, YK ;

Ercole, F ;

Krstina, J ;

Jeffery, J ;

Le, TPT ;

Mayadunne, RTA ;

Meijs, GF ;

Moad, CL ;

Moad, G ;

Rizzardo, E ;

Thang, SH .

MACROMOLECULES, 1998, 31 (16) :5559-5562

[8] Synthesis of MUC1 Peptide and Glycopeptide Dendrimers [J].

Chun, Candy K. Y. ;

Payne, Richard J. .

AUSTRALIAN JOURNAL OF CHEMISTRY, 2009, 62 (10) :1339-1343

[9] Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3+2] dipolar cycloaddition reaction [J].

Dirks, AJT ;

van Berkel, SS ;

Hatzakis, NS ;

Opsteen, JA ;

van Delft, FL ;

Cornelissen, JJLM ;

Rowan, AE ;

van Hest, JCM ;

Rutjes, FPJT ;

Nolte, RJM .

CHEMICAL COMMUNICATIONS, 2005, (33) :4172-4174

[10] The dawning era of polymer therapeutics [J].

Duncan, R .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :347-360

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