Genetically predicted serum urate levels have no causal role on depression or other psychiatric disorders

被引:6
作者
Zhao, Sizheng Steven [1 ]
Qian, Yu [2 ]
Mackie, Sarah L. [3 ,4 ]
Wen, Chengping [2 ]
Mao, Yingying [2 ]
机构
[1] Univ Liverpool, Inst Life Course & Med Sci, Musculoskeletal Biol, Liverpool, Merseyside, England
[2] Zhejiang Chinese Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hangzhou 310053, Zhejiang, Peoples R China
[3] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England
[4] Univ Leeds, Natl Inst Hlth Res, Leeds Teaching Hosp, Leeds Biomed Res Ctr, Leeds, W Yorkshire, England
基金
中国国家自然科学基金;
关键词
Anxiety; Depression; Gout; Mendelian randomization; Mental health; Urate;
D O I
10.1007/s10067-021-05718-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Clinicians are advised caution in reducing serum urate for gout management due to observational associations with risk of neuropsychiatric diseases. We examined the causal effect of genetically predicted serum urate levels on the risk of major depressive disorder (MDD), anxiety, and related psychiatric disorders using two-sample Mendelian randomization (MR). We identified single-nucleotide polymorphisms (SNPs) associated with serum urate from a genome-wide association study (GWAS) of 110,347 European-descent individuals. The causal effect of serum urate on MDD was tested using summary data from a GWAS of 135,458 cases and 344,901 controls of European descent. MR was performed using random-effects inverse variance-weighted method and a series of sensitivity analyses. This approach was repeated using summary GWAS data for anxiety, bipolar disorder, post-traumatic stress disorder, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, schizophrenia, and anorexia nervosa. We identified 30 SNPs associated with serum urate. Genetically predicted urate levels were not causally associated with risk of MDD (OR 0.98; 95% CI 0.94, 1.03), anxiety (OR 0.90; 95% CI 0.80, 1.02), or the other psychiatric conditions (OR range 0.95 to 1.06). Results were similar in sensitivity analyses. We found no evidence that genetically predicted serum urate has a causal effect on risk of MDD, anxiety, or other psychiatric disorders.
引用
收藏
页码:3729 / 3733
页数:5
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