Canned food intake and urinary bisphenol a concentrations: a randomized crossover intervention study

被引:24
|
作者
Peng, Chiung-Yu [1 ,2 ]
Tsai, Eing-Mei [2 ,3 ,4 ,5 ]
Kao, Tzu-Hsiung [1 ]
Lai, Tai-Cheng [1 ]
Liang, Shih-Shin [3 ,6 ]
Chiu, Chien-Chih [6 ]
Wang, Tsu-Nai [1 ,2 ]
机构
[1] Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan
[3] Kaohsiung Med Univ, Ctr Resources Res & Dev, Kaohsiung, Taiwan
[4] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
[5] Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung, Taiwan
[6] Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung, Taiwan
关键词
Canned foods; Bisphenol A; Intervention; Crossover study; Exposure route; HUMAN EXPOSURE; HUMAN HEALTH; DIETARY; BPA; OBESITY; ADULT; INDICATORS; BEHAVIORS; SAMPLES; HUMANS;
D O I
10.1007/s11356-019-05534-y
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Bisphenol A (BPA) is an endocrine disruptor. To evaluate the effect of canned food consumption on internal BPA dose, urinary BPA concentrations were measured before and after intake of canned foods. This study applied a randomized crossover design, recruited 20 healthy volunteers, and divided them into two groups. One group consumed canned food; the other group consumed fresh food. After a 1-day washout, the dietary interventions were reversed. In each period, urine samples were collected immediately before meals and then 2 h, 4 h, and 6 h after meals. A mixed-effects model was used to assess BPA changes over time. Our results showed urinary BPA concentrations increased after consumption of canned food. Specifically, urinary BPA concentrations significantly differed between consumption of canned food and fresh food at 2 h, 4 h, and 6 h after intake (p values of 0.001, < 0.001, and < 0.001, respectively). Mean BPA concentrations at 2 h, 4 h, and 6 h after meals were 152%, 206%, and 79% higher, respectively, than mean BPA concentrations before meals. Urine concentration profiles of canned food intake showed that peaks were at 4 h, the increase diminished at 6 h, and returned to baseline levels at 24 h after intake. Therefore, dietary intervention and a 1-day washout period are effective for limiting internal BPA burden. This study provides convincing evidence of a human exposure route to BPA and a basis for designing interventions to mitigate exposure.
引用
收藏
页码:27999 / 28009
页数:11
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