Feasibility of Low-volume Injections of Contrast Material with a Body Weight-Adapted Iodine-Dose Protocol in 320-Detector Row Coronary CT Angiography

Rationale and Objectives: To investigate the feasibility of low-volume injections of contrast material with a body weight-adapted iodine-dose protocol in computed tomography coronary angiography (CTCA) using a 320-detector row scanner. Materials and Methods: Ninety-eight patients who underwent CTCA in a single heartbeat with electrocardiogram-gating were divided into two groups, receiving 0.8 mL/kg of contrast material injected at a fixed duration of 12 seconds (A; n = 48) or 0.7 mL/kg of contrast material injected at a fixed duration of 10 seconds (13; n = 50); all patients then received 20 mL of saline. Contrast densities were assessed for the ascending aorta, left ventricle, right coronary artery (RCA), and left main coronary artery (LMA). Results: The mean flow rate was 4.00 +/- 0.56 mL/second in group A and 4.06 +/- 0.57 mL/second in group B (P = .51). There were no significant differences in the mean enhancement values of the ascending aorta, LMA and proximal RCA between the two groups. Also, there was no significant difference between the mean enhancement values at the three different levels of the RCA (proximal, middle, and distal segments) (group A; P = .27, group B; P = .07). Conclusion: The use of 0.7 mL/kg of contrast material injected at a fixed duration of 10 seconds was feasible for CTCA using 320-detector row CT, with a sufficient and reliable contrast enhancement in the ascending aorta and coronary artery.