Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents

被引：30
作者：
An, Hyang Mi [1 ]
Baek, Eun Hye [1 ]
Jang, Seok [1 ]
Lee, Do Kyung [1 ]
Kim, Mi Jin [1 ]
Kim, Jung Rae [1 ]
Lee, Kang Oh [2 ]
Park, Jong Gi [3 ]
Ha, Nam Joo [1 ]
机构：
[1] Sahmyook Univ, Dept Pharm, Seoul 139742, South Korea
[2] Sahmyook Univ, Dept Life Sci, Seoul 139742, South Korea
[3] Eden Adventist Hosp, Gyeonggi Do 472851, South Korea
来源：
NUTRITION JOURNAL | 2010年 / 9卷
关键词：
Lactic Acid Bacterium; Nursing Home Resident; Chronic Constipation; Intestinal Microflora; Intestinal Environment;
D O I：
10.1186/1475-2891-9-5
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Background: Constipation is a significant problem in the elderly, specifically nursing home and/or extended-care facility residents are reported to suffer from constipation. Lactic acid bacteria (LAB) are beneficial probiotic organisms that contribute to improved nutrition, microbial balance, and immuno-enhancement of the intestinal tract, as well as diarrhea and constipation effect. The objective of this study was to investigate the efficacy of this LAB supplement in the management of nursing home residents. Methods: Nineteen subjects (8M, 11F; mean age 77.1 +/- 10.1) suffering with chronic constipation were assigned to receive LAB (3.0 x 10(11) CFU/g) twice (to be taken 30 minutes after breakfast and dinner) a day for 2 weeks in November 2008. Subjects draw up a questionnaire on defecation habits (frequency of defecation, amount and state of stool), and we collected fecal samples from the subjects both before entering and after ending the trial, to investigate LAB levels and inhibition of harmful enzyme activities. Results were tested with SAS and Student's t-test. Results: Analysis of questionnaire showed that there was an increase in the frequency of defecation and amount of stool excreted in defecation habit after LAB treatment, but there were no significant changes. And it also affects the intestinal environment, through significantly increase (p < 0.05) fecal LAB levels. In addition, tryptophanase and urease among harmful enzyme activities of intestinal microflora were significantly decreased (p < 0.05) after LAB treatment. Conclusion: LAB, when added to the standard treatment regimen for nursing home residents with chronic constipation, increased defecation habit such as frequency of defecation, amount and state of stool. So, it may be used as functional probiotics to improve human health by helping to prevent constipation.
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页数：7
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